Title:
ADIPOCYTE ACTIVATOR
Document Type and Number:
WIPO Patent Application WO/2024/005157
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a novel adipocyte activator; and a use thereof. The present invention provides an adipocyte activator containing SerpinA1, a SerpinA1 expression promoter, or a SerpinA1 agonist, wherein the adipocyte is selected from among a brown preadipocyte, a brown adipocyte, and a beige adipocyte. An adipose tissue activator according to the present invention has an action that enhances a heat production action in adipose tissue, and can be used as a pharmaceutical composition for preventing and/or treating obesity and/or obesity-related diseases.
Inventors:
SAKAGUCHI MASAJI (JP)
ARAKI EIICHI (JP)
ARAKI EIICHI (JP)
Application Number:
PCT/JP2023/024246
Publication Date:
January 04, 2024
Filing Date:
June 29, 2023
Export Citation:
Assignee:
UNIV KUMAMOTO NAT UNIV CORP (JP)
International Classes:
A61K38/55; A61K45/00; A61K48/00; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/12; A61P13/12; A61P19/06; A61P43/00; G01N33/15
Foreign References:
| JP2018502579A | 2018-02-01 |
Other References:
WEIR GORDON C, EHLERS MARIO R, HARRIS KRISTINA M, KANAPARTHI SAI, LONG ALICE, PHIPPARD DEBORAH, WEINER LIA J, JEPSON BRETT, MCNAMA: "Alpha-1 antitrypsin treatment of new-onset type 1 diabetes: An open-label, phase I clinical trial (RETAIN) to assess safety and pharmacokinetics", PEDIATRIC DIABETES, MUNKSGAARD, COPENHAGEN, DK, vol. 19, no. 5, 1 August 2018 (2018-08-01), DK , pages 945 - 954, XP093121894, ISSN: 1399-543X, DOI: 10.1111/pedi.12660
MA HONGXIA, LU YUANQING, LOWE KEITH, VAN DER MEIJDEN-ERKELENS LONNEKE, WASSERFALL CLIVE, ATKINSON MARK A., SONG SIHONG: "Regulated hAAT Expression from a Novel rAAV Vector and Its Application in the Prevention of Type 1 Diabetes", JOURNAL OF CLINICAL MEDICINE, MULTIDISCIPLINARY DIGITAL PUBLISHING INSTITUTE (MDPI), CH, vol. 8, no. 9, 28 August 2019 (2019-08-28), CH , pages 1321, XP093121895, ISSN: 2077-0383, DOI: 10.3390/jcm8091321
MA HONGXIA, LU YUANQING, LOWE KEITH, VAN DER MEIJDEN-ERKELENS LONNEKE, WASSERFALL CLIVE, ATKINSON MARK A., SONG SIHONG: "Regulated hAAT Expression from a Novel rAAV Vector and Its Application in the Prevention of Type 1 Diabetes", JOURNAL OF CLINICAL MEDICINE, MULTIDISCIPLINARY DIGITAL PUBLISHING INSTITUTE (MDPI), CH, vol. 8, no. 9, 28 August 2019 (2019-08-28), CH , pages 1321, XP093121895, ISSN: 2077-0383, DOI: 10.3390/jcm8091321
Attorney, Agent or Firm:
OSAWA Kenichi (JP)
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