Title:
TOXICITY REDUCING AGENT FOR NUCLEIC ACID DRUG
Document Type and Number:
WIPO Patent Application WO/2024/005156
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel nucleic acid drug capable of simultaneously achieving both a high gene regulatory effect and a low toxicity. Provided is a toxicity reducing agent for a nucleic acid drug that comprises a nucleoside containing an artificial base represented by formula (I), said toxicity reducing agent being linked to a nucleic acid chain constituting the nucleic acid drug via an internucleoside linkage.
Inventors:
YOKOTA TAKANORI (JP)
YOSHIOKA KOTARO (JP)
MATSUBAYASHI TAIKI (JP)
OBIKA SATOSHI (JP)
NAKAGAWA OSAMU (JP)
YOSHIOKA KOTARO (JP)
MATSUBAYASHI TAIKI (JP)
OBIKA SATOSHI (JP)
NAKAGAWA OSAMU (JP)
Application Number:
PCT/JP2023/024244
Publication Date:
January 04, 2024
Filing Date:
June 29, 2023
Export Citation:
Assignee:
UNIV NAT CORP TOKYO MEDICAL & DENTAL (JP)
UNIV OSAKA (JP)
UNIV OSAKA (JP)
International Classes:
A61K31/7068; A61K31/7115; A61K31/712; A61K31/7125; A61K48/00; A61P25/00; A61P39/02; C07H21/04; C12N15/113
Domestic Patent References:
| WO2019181946A1 | 2019-09-26 |
Foreign References:
| US20210269797A1 | 2021-09-02 | |||
| JP2015529469A | 2015-10-08 | |||
| JP2016518826A | 2016-06-30 |
Other References:
FLANAGAN W. MICHAEL, WOLF JOHN J., OLSON PETER, GRANT DEBBIE, LIN KUEI-YING, WAGNER RICHARD W., MATTEUCCI MARK D.: "A cytosine analog that confers enhanced potency to antisense oligonucleotides", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 96, no. 7, 30 March 1999 (1999-03-30), pages 3513 - 3518, XP093048115, ISSN: 0027-8424, DOI: 10.1073/pnas.96.7.3513
KISHIMOTO YUKI, NAKAGAWA OSAMU, FUJII AKANE, YOSHIOKA KOTARO, NAGATA TETSUYA, YOKOTA TAKANORI, HARI YOSHIYUKI, OBIKA SATOSHI: "2′,4′‐BNA/LNA with 9‐(2‐Aminoethoxy)‐1,3‐diaza‐2‐oxophenoxazine Efficiently Forms Duplexes and Has Enhanced Enzymatic Resistance**", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 27, no. 7, 1 February 2021 (2021-02-01), DE, pages 2427 - 2438, XP093122126, ISSN: 0947-6539, DOI: 10.1002/chem.202003982
KISHIMOTO YUKI, NAKAGAWA OSAMU, FUJII AKANE, YOSHIOKA KOTARO, NAGATA TETSUYA, YOKOTA TAKANORI, HARI YOSHIYUKI, OBIKA SATOSHI: "2′,4′‐BNA/LNA with 9‐(2‐Aminoethoxy)‐1,3‐diaza‐2‐oxophenoxazine Efficiently Forms Duplexes and Has Enhanced Enzymatic Resistance**", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 27, no. 7, 1 February 2021 (2021-02-01), DE, pages 2427 - 2438, XP093122126, ISSN: 0947-6539, DOI: 10.1002/chem.202003982
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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