Title:
AGENT FOR AMELIORATION OF INSULIN RESISTANCE
Document Type and Number:
WIPO Patent Application WO/2007/043306
Kind Code:
A1
Abstract:
Disclosed is a pharmaceutical or beverage/food which can inhibit the production
of an adipocytokine, particularly an adipocytokine that can induce the resistance
to insulin, to thereby prevent or ameliorate the occurrence of a morbid condition
relating to insulin resistance. The pharmaceutical or beverage/food comprises,
as an active ingredient, a compound having a lophenol skeleton, or an extract
of a plant belonging to the family Liliaceae with an organic solvent or
hot water or a fractionated product of the extract which contains the compound.
Inventors:
TANAKA MIYUKI (JP)
MISAWA ERIKO (JP)
MISAWA ERIKO (JP)
Application Number:
PCT/JP2006/318815
Publication Date:
April 19, 2007
Filing Date:
September 22, 2006
Export Citation:
Assignee:
MORINAGA MILK INDUSTRY CO LTD (JP)
TANAKA MIYUKI (JP)
MISAWA ERIKO (JP)
TANAKA MIYUKI (JP)
MISAWA ERIKO (JP)
International Classes:
C07J9/00; A23L1/30; A61K36/896; A61P3/10; A61K31/575
Domestic Patent References:
| WO2005094838A1 | 2005-10-13 | |||
| WO2006035525A1 | 2006-04-06 | |||
| WO2005095436A1 | 2005-10-13 |
Foreign References:
| JP2003286185A | 2003-10-07 | |||
| JPH1036283A | 1998-02-10 | |||
| JP2000319190A | 2000-11-21 |
Other References:
OKYAR A. ET AL.: "Effect of Aloe vera leaves on blood glucose level in type I and type II diabetes rat models", PHYTOTHER. RES., vol. 15, no. 2, 2001, pages 157 - 161, XP003011588
RAJASEKARAN S. ET AL.: "Hypoglycemic Effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats", JOURNAL OF MEDICINAL FOOD, vol. 7, no. 1, 2004, pages 61 - 66, XP003011589
YONGCHAIYUDHA S. ET AL.: "Antidiabetic activity of Aloe vera L.juice. I. Clinical trial in new cases of diabetes mellitus", PHYTOMEDICINE, vol. 3, no. 3, 1996, pages 241 - 243, XP003011590
YEH G.Y. ET AL.: "Systematic review of herbs and dietary supplements for glycemic control in diabetes", DIABETES CARE, vol. 26, no. 4, 2003, pages 1277 - 1294, XP003011591
ITOH T. ET AL.: "Four new and other 4alpha-methylsterols in the seeds of Solanaceae", PHYTOCHEMISTRY, vol. 17, no. 5, 1978, pages 971 - 977, XP003011593
TANAKA M. ET AL.: "Identification of Five Phytosterols from Aloe Vera Gel as Anti-diabetic Compounds", BIOL. PHARM. BULL., vol. 26, no. 7, July 2006 (2006-07-01), pages 1418 - 1422, XP003011592
See also references of EP 1930341A4
RAJASEKARAN S. ET AL.: "Hypoglycemic Effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats", JOURNAL OF MEDICINAL FOOD, vol. 7, no. 1, 2004, pages 61 - 66, XP003011589
YONGCHAIYUDHA S. ET AL.: "Antidiabetic activity of Aloe vera L.juice. I. Clinical trial in new cases of diabetes mellitus", PHYTOMEDICINE, vol. 3, no. 3, 1996, pages 241 - 243, XP003011590
YEH G.Y. ET AL.: "Systematic review of herbs and dietary supplements for glycemic control in diabetes", DIABETES CARE, vol. 26, no. 4, 2003, pages 1277 - 1294, XP003011591
ITOH T. ET AL.: "Four new and other 4alpha-methylsterols in the seeds of Solanaceae", PHYTOCHEMISTRY, vol. 17, no. 5, 1978, pages 971 - 977, XP003011593
TANAKA M. ET AL.: "Identification of Five Phytosterols from Aloe Vera Gel as Anti-diabetic Compounds", BIOL. PHARM. BULL., vol. 26, no. 7, July 2006 (2006-07-01), pages 1418 - 1422, XP003011592
See also references of EP 1930341A4
Attorney, Agent or Firm:
KAWAGUCHI, Yoshiyuki et al. (4-10, Higashi Nihonbashi 3-chome, Chuo-ku Tokyo 04, JP)
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