Title:
AGENT FOR BINDING SUGAR CHAIN TO PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2005/095331
Kind Code:
A1
Abstract:
An agent for binding a sugar chain to a peptide which comprises a compound represented by the general formula (I): X-Y-Z (I) wherein X is H2Z- or HS-; Y is -A1-, -A1-O-A2-, -(CH2CH2O)n-A1-, -(CH2CH2O)n-A1-O-A2-, -A1-NH-C(=O)-A2-, -A1-C(=O)-NH-A2-, -A1-(CH2CH2O)n-NH-C(=O)-A2-, -A1-(CH2CH2O)n-C(=O)-NH-A2-, etc.; and Z is -O-NH(R4), -NH-OR4, -C(=O)-NH-NH-R4, or -C(=S)-NH-NH-R4 (wherein R4 is hydrogen, lower alkyl, or aryl). Also provided is a process for producing a sugar peptide with the agent for binding a sugar chain to a peptide.
Inventors:
NISHIMURA SHINICHIRO (JP)
TAKIMOTO AKIO (JP)
TAKIMOTO AKIO (JP)
Application Number:
PCT/JP2005/005810
Publication Date:
October 13, 2005
Filing Date:
March 29, 2005
Export Citation:
Assignee:
SHIONOGI & CO (JP)
NISHIMURA SHINICHIRO (JP)
TAKIMOTO AKIO (JP)
NISHIMURA SHINICHIRO (JP)
TAKIMOTO AKIO (JP)
International Classes:
A61K38/00; A61P3/10; C07B61/00; C07C271/14; C07C271/16; C07C271/62; C07K2/00; C07K7/08; C07K9/00; C12P21/02; (IPC1-7): C07C271/16; A61K38/00; A61P3/10; C07B61/00; C07C271/14; C07C271/62; C07K2/00; C07K7/08; C12P21/02
Foreign References:
| JP2002536357A | 2002-10-29 | |||
| JPH1077256A | 1998-03-24 | |||
| EP1400533A1 | 2004-03-24 | |||
| US20030149246A1 | 2003-08-07 |
Other References:
LEWIS L. ET AL: "Computation of the conventional strain energy in oxaziridine.", THEOCHEM., 2002, pages 161 - 171, XP002990888
KEINAENEN T.A. ET AL: "Derivatives of 1-aminooxy-3-aminopropane as polyamine antimetabolites: stability and effects on BHK21/C13 cells.", JOURNAL OF BIOCHEMISTRY., vol. 116, no. 5, 1994, pages 1056 - 1062, XP002990889
MIKOLA H. ET AL: "Syntheses of europium-labeled digoxin derivatives and their use in time-resolved fluoroimmunoassay.", STEROIDS., vol. 59, no. 8, 1994, pages 472 - 478, XP002025385
KEINAENEN T.A. ET AL: "Derivatives of 1-aminooxy-3-aminopropane as polyamine antimetabolites: stability and effects on BHK21/C13 cells.", JOURNAL OF BIOCHEMISTRY., vol. 116, no. 5, 1994, pages 1056 - 1062, XP002990889
MIKOLA H. ET AL: "Syntheses of europium-labeled digoxin derivatives and their use in time-resolved fluoroimmunoassay.", STEROIDS., vol. 59, no. 8, 1994, pages 472 - 478, XP002025385
Attorney, Agent or Firm:
Yamauchi, Hideaki (Intellectual Property Department, 12-4, Sagisu
5-chome, Fukushima-k, Osaka-shi Osaka, JP)
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