Title:
AGENT FOR PROMOTING NUCLEIC ACID MOLECULE UPTAKE INTO CELLS, PHARMACEUTICAL COMPOSITION, AND NOVEL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2022/118966
Kind Code:
A1
Abstract:
A purpose of the present invention is to provide an agent for promoting the uptake of nucleic acid molecules into cells. The present invention relates to, inter alia, an agent for promoting the uptake of nucleic acid molecules into cells, the agent containing a substance that activates at least one channel selected from the group consisting of TRPC3 channels, TRPC6 channels, and TRPC7 channels, or a pharmaceutically acceptable salt thereof, or a prodrug of these.
Inventors:
MORI YASUO (JP)
NAGATA RYU (JP)
SHIMOJO MASAHITO (JP)
OBIKA SATOSHI (JP)
NAGATA RYU (JP)
SHIMOJO MASAHITO (JP)
OBIKA SATOSHI (JP)
Application Number:
PCT/JP2021/044526
Publication Date:
June 09, 2022
Filing Date:
December 03, 2021
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
A61K45/00; A61K31/05; A61K31/454; A61K31/495; A61K31/496; A61K31/7088; A61K31/7105; A61K31/713; A61K48/00; A61P11/00; A61P13/12; A61P21/02; A61P25/02; A61P25/14; A61P25/16; A61P35/00; A61P43/00; C12N5/10; C12N15/113; C12N15/87
Domestic Patent References:
| WO2014192865A1 | 2014-12-04 |
Foreign References:
| JP2013116858A | 2013-06-13 | |||
| JPH09511764A | 1997-11-25 | |||
| JP2008253188A | 2008-10-23 |
Other References:
SEISHIRO SAWAMURA, MASAHIKO HATANO, YOSHINORI TAKADA, KYOSUKE HINO, TETSUYA KAWAMURA, JUN TANIKAWA, HIROSHI NAKAGAWA, HIDEHARU HAS: "Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds", MOLECULAR PHARMACOLOGY, vol. 89, no. 3, 10 March 2016 (2016-03-10), US , pages 348 - 363, XP055697485, ISSN: 0026-895X, DOI: 10.1124/mol.115.102863
LIU ZHAOWEI; DU ZHANQIANG; LI KAI; HAN YANGGUANG; REN GUOGANG; YANG ZHUO: "TRPC6-Mediated CaEntry Essential for the Regulation of Nano-ZnO Induced Autophagy in SH-SY5Y Cells", NEUROCHEMICAL RESEARCH, vol. 45, no. 7, 9 April 2020 (2020-04-09), New York, pages 1602 - 1613, XP037171962, ISSN: 0364-3190, DOI: 10.1007/s11064-020-03025-y
GAO NA; WANG HUI; YIN HONGQIANG; YANG ZHUO: "Angiotensin II induces calcium-mediated autophagy in podocytes through enhancing reactive oxygen species levels", CHEMICO-BIOLOGICAL INTERACTIONS, vol. 277, 1 January 1900 (1900-01-01), IR , pages 110 - 118, XP085240853, ISSN: 0009-2797, DOI: 10.1016/j.cbi.2017.09.010
HAO FENGJIN; FENG YUEQIN: "Cannabidiol (CBD) enhanced the hippocampal immune response and autophagy of APP/PS1 Alzheimer's mice uncovered by RNA-seq", LIFE SCIENCE, vol. 264, 21 October 2020 (2020-10-21), GB , XP086413463, ISSN: 0024-3205, DOI: 10.1016/j.lfs.2020.118624
A. SHRIVASTAVA, P. M. KUZONTKOSKI, J. E. GROOPMAN, A. PRASAD: "Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy", MOLECULAR CANCER THERAPEUTICS, vol. 10, no. 7, 1 July 2011 (2011-07-01), US , pages 1161 - 1172, XP055418898, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-10-1100
GEMA GUEDES DE LA CRUZ, BARBORA SVOBODOVA, MICHAELA LICHTENEGGER, OLEKSANDRA TIAPKO, KLAUS GROSCHNER, TOMA GLASNOV: "Intensified Microwave-Assisted N-Acylation Procedure – Synthesis and Activity Evaluation of TRPC3 Channel Agonists with a 1,3-Dihydro-2H-benzo[d]imidazol-2-one Core", SYNLETT, vol. 28, no. 06, DE , pages 695 - 700, XP055722074, ISSN: 0936-5214, DOI: 10.1055/s-0036-1589472
YAMASHITA TAKAYUKI: "Ca2+-dependent regulation of synaptic vesicle endocytosis", NEUROSCIENCE RESEARCH, vol. 73, no. 1, 1 May 2012 (2012-05-01), IR , pages 1 - 7, XP055935975, ISSN: 0168-0102, DOI: 10.1016/j.neures.2012.02.012
LIU ZHAOWEI; DU ZHANQIANG; LI KAI; HAN YANGGUANG; REN GUOGANG; YANG ZHUO: "TRPC6-Mediated CaEntry Essential for the Regulation of Nano-ZnO Induced Autophagy in SH-SY5Y Cells", NEUROCHEMICAL RESEARCH, vol. 45, no. 7, 9 April 2020 (2020-04-09), New York, pages 1602 - 1613, XP037171962, ISSN: 0364-3190, DOI: 10.1007/s11064-020-03025-y
GAO NA; WANG HUI; YIN HONGQIANG; YANG ZHUO: "Angiotensin II induces calcium-mediated autophagy in podocytes through enhancing reactive oxygen species levels", CHEMICO-BIOLOGICAL INTERACTIONS, vol. 277, 1 January 1900 (1900-01-01), IR , pages 110 - 118, XP085240853, ISSN: 0009-2797, DOI: 10.1016/j.cbi.2017.09.010
HAO FENGJIN; FENG YUEQIN: "Cannabidiol (CBD) enhanced the hippocampal immune response and autophagy of APP/PS1 Alzheimer's mice uncovered by RNA-seq", LIFE SCIENCE, vol. 264, 21 October 2020 (2020-10-21), GB , XP086413463, ISSN: 0024-3205, DOI: 10.1016/j.lfs.2020.118624
A. SHRIVASTAVA, P. M. KUZONTKOSKI, J. E. GROOPMAN, A. PRASAD: "Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy", MOLECULAR CANCER THERAPEUTICS, vol. 10, no. 7, 1 July 2011 (2011-07-01), US , pages 1161 - 1172, XP055418898, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-10-1100
GEMA GUEDES DE LA CRUZ, BARBORA SVOBODOVA, MICHAELA LICHTENEGGER, OLEKSANDRA TIAPKO, KLAUS GROSCHNER, TOMA GLASNOV: "Intensified Microwave-Assisted N-Acylation Procedure – Synthesis and Activity Evaluation of TRPC3 Channel Agonists with a 1,3-Dihydro-2H-benzo[d]imidazol-2-one Core", SYNLETT, vol. 28, no. 06, DE , pages 695 - 700, XP055722074, ISSN: 0936-5214, DOI: 10.1055/s-0036-1589472
YAMASHITA TAKAYUKI: "Ca2+-dependent regulation of synaptic vesicle endocytosis", NEUROSCIENCE RESEARCH, vol. 73, no. 1, 1 May 2012 (2012-05-01), IR , pages 1 - 7, XP055935975, ISSN: 0168-0102, DOI: 10.1016/j.neures.2012.02.012
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Download PDF:
Previous Patent: SENSOR DEVICE, AND METHOD FOR PRODUCING SENSOR DEVICE
Next Patent: LAMINATED FILM AND MOLDED ARTICLE, AND PRODUCTION METHODS THEREFOR
Next Patent: LAMINATED FILM AND MOLDED ARTICLE, AND PRODUCTION METHODS THEREFOR