Title:
AGENT FOR PROMOTING PROLIFERATION AND/OR DIFFERENTIATION OF PREADIPOCYTE, CONTAINING HELENALIN DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2023/223715
Kind Code:
A1
Abstract:
[Problem] To discover a compound that is contained in an arnica extract and that promotes proliferation and/or differentiation of preadipocytes, and to provide, by using said compound, a cosmetic product, a food product, a medicinal product, etc., and/or a material to be blended therein, all of which for increasing the volume of a fat layer to create a beautiful appearance. [Solution] This agent is for promoting proliferation and/or differentiation of preadipocytes, and contains, as an active ingredient, a compound represented by formula (I) (in the formula, R represents a hydrogen atom or an acyl group having 1-5 carbon atoms).
Inventors:
SAKAMOTO KOTARO (JP)
MITSUNAGA TOHRU (JP)
YAMAUCHI KOSEI (JP)
MITSUNAGA TOHRU (JP)
YAMAUCHI KOSEI (JP)
Application Number:
PCT/JP2023/014689
Publication Date:
November 23, 2023
Filing Date:
April 11, 2023
Export Citation:
Assignee:
ICHIMARU PHARCOS INC (JP)
International Classes:
A61K31/365; A23L33/105; A61K8/49; A61K36/28; A61P3/06; A61P17/00; A61Q19/00
Foreign References:
| JP2020023476A | 2020-02-13 | |||
| JP2011032233A | 2011-02-17 |
Other References:
FERNANDES KARISHMA M., AULD CORINTH A., HOPKINS ROBIN G., MORRISON RON F.: "Helenalin‐mediated post‐transcriptional regulation of p21(Cip1) inhibits 3T3‐L1 preadipocyte proliferation", JOURNAL OF CELLULAR BIOCHEMISTRY, JOHN WILEY & SONS, INC. JOHN WILEY & SONS, INC., HOBOKEN, USA, vol. 105, no. 3, 15 October 2008 (2008-10-15), Hoboken, USA, pages 913 - 921, XP093108903, ISSN: 0730-2312, DOI: 10.1002/jcb.21894
AULD, C.A. ; HOPKINS, R.G. ; FERNANDES, K.M. ; MORRISON, R.F.: "Novel effect of helenalin on Akt signaling and Skp2 expression in 3T3-L1 preadipocytes", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 346, no. 1, 21 July 2006 (2006-07-21), Amsterdam NL , pages 314 - 320, XP024925321, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2006.05.117
SAKAMOTO KOTARO, WATANABE CHIHARU, MASUTANI TERUAKI, HIRASAWA ASUKA, WAKAMATSU KANAE, IDDAMALGODA ARUNASIRI, KAKUMU YUYA, YAMAUCHI: "Arnica montana L. extract containing 6-Omethacryloylhelenalin and 6-O-isobutyrylhelenalin accelerates growth and differentiation of human subcutaneous preadipocytes and leads volumizing of skin", INTERNATIONAL JOURNAL OF COSMETIC SCIENCE., KLUWER ACADEMIC PUBLISHERS, DORDRECHT., NL, vol. 45, no. 1, 1 February 2023 (2023-02-01), NL , pages 1 - 13, XP093108911, ISSN: 0142-5463, DOI: 10.1111/ics.12815
AULD, C.A. ; HOPKINS, R.G. ; FERNANDES, K.M. ; MORRISON, R.F.: "Novel effect of helenalin on Akt signaling and Skp2 expression in 3T3-L1 preadipocytes", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 346, no. 1, 21 July 2006 (2006-07-21), Amsterdam NL , pages 314 - 320, XP024925321, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2006.05.117
SAKAMOTO KOTARO, WATANABE CHIHARU, MASUTANI TERUAKI, HIRASAWA ASUKA, WAKAMATSU KANAE, IDDAMALGODA ARUNASIRI, KAKUMU YUYA, YAMAUCHI: "Arnica montana L. extract containing 6-Omethacryloylhelenalin and 6-O-isobutyrylhelenalin accelerates growth and differentiation of human subcutaneous preadipocytes and leads volumizing of skin", INTERNATIONAL JOURNAL OF COSMETIC SCIENCE., KLUWER ACADEMIC PUBLISHERS, DORDRECHT., NL, vol. 45, no. 1, 1 February 2023 (2023-02-01), NL , pages 1 - 13, XP093108911, ISSN: 0142-5463, DOI: 10.1111/ics.12815
Attorney, Agent or Firm:
MEBUKI IP LAW FIRM et al. (JP)
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