Title:
AGENT FOR SUPPRESSING IL-31 PRODUCTION AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2022/168962
Kind Code:
A1
Abstract:
The present invention provides an agent for suppressing interleukin 31 (IL-31) production and a pharmaceutical composition containing the same. The present invention also provides a novel compound that is effective as an active ingredient of the agent for suppressing IL-31 production. These contain a compound represented by formula (1) or a salt thereof as an active ingredient. (In formula (1): A is a -NH-N=C (R1)- group, a divalent nitrogen-containing 5-membered heterocyclic group, or a -NH-CO- group; the R1 is a hydrogen atom or a C1-4 alkyl group; B is the same or different, is a C1-6 alkyl group that may have one hydroxyl group, a mono- or di-(C1-6 alkyl) amino group that may have one hydroxyl group, a halogen atom, a halo C1-6 alkyl group, a C2-6 alkynylene group, or a carboxy group; the C1-6 alkyl group of the mono- or di-(C1-6 alkyl)-amino group may bond to a carbon atom adjacent to the carbon atom of the phenyl group to which it is bonded to form a 5 to 6-membered ring; and n is an integer between1 and 5.)
Inventors:
FUKUI YOSHINORI (JP)
URUNO TAKEHITO (JP)
KANAI MOTOMU (JP)
OISAKI KOUNOSUKE (JP)
SAIKI KUNIKO (JP)
URUNO TAKEHITO (JP)
KANAI MOTOMU (JP)
OISAKI KOUNOSUKE (JP)
SAIKI KUNIKO (JP)
Application Number:
PCT/JP2022/004558
Publication Date:
August 11, 2022
Filing Date:
February 04, 2022
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
UNIV TOKYO (JP)
UNIV TOKYO (JP)
International Classes:
A61K31/192; A61K31/194; A61K31/196; A61K31/4192; A61K31/421; A61K31/4745; A61P17/04; A61P43/00; C07K7/08; C12N15/09
Domestic Patent References:
| WO2010053606A2 | 2010-05-14 | |||
| WO2007043400A1 | 2007-04-19 |
Foreign References:
| JP2008530104A | 2008-08-07 | |||
| JPH02250856A | 1990-10-08 | |||
| JP2018505860A | 2018-03-01 | |||
| JP2008515985A | 2008-05-15 |
Other References:
CHE DENIS NCHANG, CHO BYOUNG OK, SHIN JAE YOUNG, KANG HYUN JU, KIM YOUNG-SOO, JANG SEON IL: "Fisetin inhibits IL-31 production in stimulated human mast cells: Possibilities of fisetin being exploited to treat histamine-independent pruritus", LIFE SCIENCE, vol. 201, 1 May 2018 (2018-05-01), GB , pages 121 - 129, XP055959067, ISSN: 0024-3205, DOI: 10.1016/j.lfs.2018.03.056
CHE DENIS NCHANG; CHO BYOUNG OK; KIM JI-SU; SHIN JAE YOUNG; KANG HYUN JU; JANG SEON IL: "Luteolin and Apigenin Attenuate LPS-Induced Astrocyte Activation and Cytokine Production by Targeting MAPK, STAT3, and NF-κB Signaling Pathways", INFLAMMATION, vol. 43, no. 5, 27 May 2020 (2020-05-27), US , pages 1716 - 1728, XP037239214, ISSN: 0360-3997, DOI: 10.1007/s10753-020-01245-6
KAMIKASEDA YASUHISA; URUNO TAKEHITO; KUNIMURA KAZUFUMI; HARADA AKIHITO; SAIKI KUNIKO; OISAKI KOUNOSUKE; SAKATA DAIJI; NAKAHARA TAK: "Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 148, no. 2, 2 April 2021 (2021-04-02), AMSTERDAM, NL , pages 633 - 638, XP086720550, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2021.03.029
KUNIMURA KAZUFUMI, FUKUI YOSHINORI: "The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development", INTERNATIONAL IMMUNOLOGY, vol. 33, no. 12, 25 November 2021 (2021-11-25), pages 731 - 736, XP055933629, DOI: 10.1093/intimm/dxab065
FURUE MYAMAMURA KKIDO-NAKAHARA MNAKAHARA TFUKUI Y. EMERGING: "role of interleukin - 31 and interleukin - 31 receptor in pruritus in atopic dermatitis", ALLERGY, vol. 73, 2018, pages 29 - 36, XP055588801, DOI: 10.1111/all.13239
KABASHIMA KFURUE MHANIFIN JMPULKA GWOLLENBERG AGALUS R ET AL.: "Nemolizumab in patients with moderate-to-severe atopic dermatitis", RANDOMIZED, PHASE II, LONG-TERM EXTENSION STUDY. J ALLERGY CLIN IMMUNOL, vol. 142, 2018, pages 1121 - 1130
ZHANG QDAVIS JCDOVE CG: "Su HC. Genetic, clinical, and laboratory markers for DOCK8 immunodeficiency syndrome", DIS MARKERS, vol. 29, 2010, pages 131 - 9
YAMAMURA KURUNO TSHIRAISHI ATANAKA YUSHIJIMA MNAKAHARA T ET AL.: "The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction", NAT COMMUN, vol. 8, 2017, pages 13946
KOK-FUI LKIT-LAM CCHONG-YEW L. EUR., J. MED. CHEM., vol. 94, 2015, pages 195
TIAN HMCKNIGHT SLRUSSELL DW.: "Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells", GENES DEV, vol. 11, 1997, pages 72 - 82
MORENO-MANZANO VRODRIGUEZ-JIMENEZ FJACENA-BONILLA JLFUSTERO-LARDIES SERCEG SDOPAZO J ET AL.: "FM19G11, a New Hypoxia-inducible Factor (HIF) Modulator, Affects Stem Cell Differentiation Status", J BIOL CHEM, vol. 285, 2010, pages 1333 - 42, XP055061864, DOI: 10.1074/jbc.M109.008326
PENG TQI BHE JKE HSHI J.: "Advances in the Development of Phosphodiesterase-4 Inhibitors", J MED CHEM, vol. 63, 2020, pages 10594 - 10617
CHE DENIS NCHANG; CHO BYOUNG OK; KIM JI-SU; SHIN JAE YOUNG; KANG HYUN JU; JANG SEON IL: "Luteolin and Apigenin Attenuate LPS-Induced Astrocyte Activation and Cytokine Production by Targeting MAPK, STAT3, and NF-κB Signaling Pathways", INFLAMMATION, vol. 43, no. 5, 27 May 2020 (2020-05-27), US , pages 1716 - 1728, XP037239214, ISSN: 0360-3997, DOI: 10.1007/s10753-020-01245-6
KAMIKASEDA YASUHISA; URUNO TAKEHITO; KUNIMURA KAZUFUMI; HARADA AKIHITO; SAIKI KUNIKO; OISAKI KOUNOSUKE; SAKATA DAIJI; NAKAHARA TAK: "Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 148, no. 2, 2 April 2021 (2021-04-02), AMSTERDAM, NL , pages 633 - 638, XP086720550, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2021.03.029
KUNIMURA KAZUFUMI, FUKUI YOSHINORI: "The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development", INTERNATIONAL IMMUNOLOGY, vol. 33, no. 12, 25 November 2021 (2021-11-25), pages 731 - 736, XP055933629, DOI: 10.1093/intimm/dxab065
FURUE MYAMAMURA KKIDO-NAKAHARA MNAKAHARA TFUKUI Y. EMERGING: "role of interleukin - 31 and interleukin - 31 receptor in pruritus in atopic dermatitis", ALLERGY, vol. 73, 2018, pages 29 - 36, XP055588801, DOI: 10.1111/all.13239
KABASHIMA KFURUE MHANIFIN JMPULKA GWOLLENBERG AGALUS R ET AL.: "Nemolizumab in patients with moderate-to-severe atopic dermatitis", RANDOMIZED, PHASE II, LONG-TERM EXTENSION STUDY. J ALLERGY CLIN IMMUNOL, vol. 142, 2018, pages 1121 - 1130
ZHANG QDAVIS JCDOVE CG: "Su HC. Genetic, clinical, and laboratory markers for DOCK8 immunodeficiency syndrome", DIS MARKERS, vol. 29, 2010, pages 131 - 9
YAMAMURA KURUNO TSHIRAISHI ATANAKA YUSHIJIMA MNAKAHARA T ET AL.: "The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction", NAT COMMUN, vol. 8, 2017, pages 13946
KOK-FUI LKIT-LAM CCHONG-YEW L. EUR., J. MED. CHEM., vol. 94, 2015, pages 195
TIAN HMCKNIGHT SLRUSSELL DW.: "Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells", GENES DEV, vol. 11, 1997, pages 72 - 82
MORENO-MANZANO VRODRIGUEZ-JIMENEZ FJACENA-BONILLA JLFUSTERO-LARDIES SERCEG SDOPAZO J ET AL.: "FM19G11, a New Hypoxia-inducible Factor (HIF) Modulator, Affects Stem Cell Differentiation Status", J BIOL CHEM, vol. 285, 2010, pages 1333 - 42, XP055061864, DOI: 10.1074/jbc.M109.008326
PENG TQI BHE JKE HSHI J.: "Advances in the Development of Phosphodiesterase-4 Inhibitors", J MED CHEM, vol. 63, 2020, pages 10594 - 10617
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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