Title:
ALBIZIAE CORTEX LIGNAN COMPOUND AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/063075
Kind Code:
A1
Abstract:
The present invention relates to the technical field of biomedicine, and disclosed are an albiziae cortex lignan compound and an application thereof. The compound prepared by the present invention can effectively treat FFAs-induced lipid metabolism disorders and fatty degeneration at a concentration, and can enable the lipid droplet area to reduce by about 3 times at an administration concentration of 20 μM 24 h after administration; the compound can significantly enhance cell activity of HUVEC and significantly promote self-replication of cells, so as to promote proliferation of endothelial cell HUVEC. The cell viability can reach 242.233% in control at an administration concentration of 40 μM 24 h after administration. The compound prepared by the present invention can significantly inhibit the production of HG-induced reactive oxygen species (ROS) of the HUVEC cells, and can reduce the average fluorescence intensity of an HG group from 818.37% to 176.36%.
Inventors:
QIU LIYING (CN)
SHI XUELIN (CN)
HOU BAO (CN)
NI LULU (CN)
CAI WEIWEI (CN)
XU FEI (CN)
SUN JIANGNAN (CN)
LI SHUANGSHUANG (CN)
SHI XUELIN (CN)
HOU BAO (CN)
NI LULU (CN)
CAI WEIWEI (CN)
XU FEI (CN)
SUN JIANGNAN (CN)
LI SHUANGSHUANG (CN)
Application Number:
PCT/CN2020/102544
Publication Date:
April 08, 2021
Filing Date:
July 17, 2020
Export Citation:
Assignee:
UNIV JIANGNAN (CN)
International Classes:
C07H15/18; A23L33/105; A61K8/60; A61K31/7028; A61K31/7032; A61K36/48; A61P1/16; A61P3/00; A61P3/06; A61P3/10; A61P9/00; A61P35/00; A61P35/04; A61P39/06; A61Q19/08; C07H1/08; C07H15/203; C09K15/08
Foreign References:
| CN110563781A | 2019-12-13 | |||
| CN110590873A | 2019-12-20 | |||
| CN110638821A | 2020-01-03 | |||
| CN111110687A | 2020-05-08 | |||
| CN108530500A | 2018-09-14 | |||
| CN104151373A | 2014-11-19 | |||
| CN105030802A | 2015-11-11 | |||
| KR20160050191A | 2016-05-11 |
Other References:
KENSAKU TAKARA, ET AL.: "New phenolic compounds from Kokuto, non-centrifuged cane sugar", BIOSCIENCE BIOTECHNOLOGY BIOCHEMISTRY, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY AND AGROCHEMISTRY, JP, vol. 67, no. 2, 1 February 2003 (2003-02-01), JP, pages 376 - 379, XP055322030, ISSN: 0916-8451, DOI: 10.1271/bbb.67.376
ZHANG XIN, LI JIAN-KUAN, ZHAO YU-JING, GAO JIAN-PING: "Analysis of Chemical Constituents in Codonopsis Ｒadix and Its in Vitro Antioxidant Activities", CHINESE JOURNAL OF EXPERIMENTAL TRADITIONAL MEDICAL FORMULAE, vol. 24, no. 24, 1 December 2018 (2018-12-01), pages 53 - 59, XP055796856, DOI: 10.13422/j.cnki.syfjx.20182105
ZHANG XIN, LI JIAN-KUAN, ZHAO YU-JING, GAO JIAN-PING: "Analysis of Chemical Constituents in Codonopsis Ｒadix and Its in Vitro Antioxidant Activities", CHINESE JOURNAL OF EXPERIMENTAL TRADITIONAL MEDICAL FORMULAE, vol. 24, no. 24, 1 December 2018 (2018-12-01), pages 53 - 59, XP055796856, DOI: 10.13422/j.cnki.syfjx.20182105
Attorney, Agent or Firm:
HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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