Title:
ALKYNE DERIVATIVE, PREPARATION METHOD FOR SAME, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/004421
Kind Code:
A1
Abstract:
The present invention relates to an alkyne derivative, a preparation method for same, and applications thereof in medicine. Specifically, the present invention relates to the alkyne derivative as represented by formula (I), the preparation method for same, a pharmaceutically acceptable salt thereof, and uses of them as a therapeutic agent, specifically as a phosphoinositide 3-kinase γ (PI3Kγ) inhibitor, where the definitions of the substituents in formula (I) are identical to the definitions in the description.
Inventors:
LV HEJUN (CN)
MA YUTAO (CN)
QIU HAIBO (CN)
ZHAO WENWEN (CN)
HU TAISHAN (CN)
CHEN LEI (CN)
MA YUTAO (CN)
QIU HAIBO (CN)
ZHAO WENWEN (CN)
HU TAISHAN (CN)
CHEN LEI (CN)
Application Number:
PCT/CN2020/100376
Publication Date:
January 14, 2021
Filing Date:
July 06, 2020
Export Citation:
Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
HISUN ACCURAY THERAPEUTICS CO LTD (CN)
HISUN ACCURAY THERAPEUTICS CO LTD (CN)
International Classes:
C07D487/04; A61K31/519; A61K45/06; A61P11/00; A61P11/06; A61P19/00; A61P29/00; A61P35/00; A61P35/02; A61P37/00
Domestic Patent References:
| WO2017214269A1 | 2017-12-14 | |||
| WO2015051244A1 | 2015-04-09 | |||
| WO2012052753A1 | 2012-04-26 | |||
| WO2011008302A1 | 2011-01-20 | |||
| WO2015134701A1 | 2015-09-11 |
Foreign References:
| CN105793255A | 2016-07-20 | |||
| CN106456628A | 2017-02-22 | |||
| US20180105527A1 | 2018-04-19 |
Other References:
MATTHEW WD ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, no. 10, 2019, pages 4783 - 4814
PERROTTA ET AL., INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 17, no. 11, 2016
OKKENHAUGKLAUS ET AL., CANCER DISCOVERY, vol. 6, no. 10, 2016, pages 1090 - 1105
HIRSCH E ET AL., SCIENCE, vol. 287, 2000, pages 1049 - 1053
LI Z. ET AL., SCIENCE, vol. 287, pages 1046 - 1049
KANEDA MM ET AL., NATURE, 2016, pages 1 - 21
J. MED. CHEM., vol. 43, 2003, pages 3434 - 3442
See also references of EP 3998270A4
PERROTTA ET AL., INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 17, no. 11, 2016
OKKENHAUGKLAUS ET AL., CANCER DISCOVERY, vol. 6, no. 10, 2016, pages 1090 - 1105
HIRSCH E ET AL., SCIENCE, vol. 287, 2000, pages 1049 - 1053
LI Z. ET AL., SCIENCE, vol. 287, pages 1046 - 1049
KANEDA MM ET AL., NATURE, 2016, pages 1 - 21
J. MED. CHEM., vol. 43, 2003, pages 3434 - 3442
See also references of EP 3998270A4
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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