AMIDINO-UREA SEROTONIN RECEPTOR LIGANDS AND COMPOSITIONS, THEIR PHARMACEUTICAL USES, AND METHODS FOR THEIR SNYTHESIS

Title:

AMIDINO-UREA SEROTONIN RECEPTOR LIGANDS AND COMPOSITIONS, THEIR PHARMACEUTICAL USES, AND METHODS FOR THEIR SNYTHESIS

Document Type and Number:

WIPO Patent Application WO2002036554

Kind Code:

A3

Abstract:

Novel amidino-urea 5-HT7 receptor ligands, methods of preparing such ligands, intermediate compounds useful in the preparation of the receptor ligands, pharmaceutical compositions comprising the receptor ligands, and methods of treating sleep disorders, pain, depression, and schizophrenia employing the receptor ligands are disclosed. The receptor ligands have formula (1): wherein the formula variables are as defined herein, and pharmaceutically acceptable salts, solvates, active metabolites, or prodrugs thereof.

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Inventors:

HONG YUFENG (US)
KUKI ATSUO (US)
TOMPKINS EILEEN VALENZUELA (US)
PENG ZHENGWEI (US)
LUTHIN DAVID ROBERT (US)

Application Number:

PCT/IB2001/002022

Publication Date:

March 13, 2003

Filing Date:

October 26, 2001

Export Citation:

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Assignee:

WARNER LAMBERT CO (US)
HONG YUFENG (US)
KUKI ATSUO (US)
TOMPKINS EILEEN VALENZUELA (US)
PENG ZHENGWEI (US)
LUTHIN DAVID ROBERT (US)

International Classes:

C07D295/20; A61K31/175; A61K31/381; A61K31/40; A61K31/4045; A61K31/4164; A61K31/437; A61K31/4402; A61K31/4406; A61K31/445; A61K31/4465; A61K31/4468; A61K31/4525; A61K31/454; A61K31/472; A61K31/495; A61P25/04; A61P25/18; A61P25/20; A61P25/24; A61P43/00; C07C279/22; C07C279/24; C07C323/48; C07D207/09; C07D209/14; C07D209/16; C07D211/16; C07D211/26; C07D211/58; C07D211/60; C07D211/62; C07D213/36; C07D213/40; C07D217/06; C07D233/61; C07D233/64; C07D235/30; C07D295/215; C07D333/20; C07D405/06; C07D413/06; C07D471/10; C07D521/00; (IPC1-7): C07C279/24; A61K31/155; A61P25/24; C07C279/22; C07D211/26; C07D211/60; C07D233/61; C07D295/20

Domestic Patent References:

WO1998007420A1	1998-02-26
WO1999020599A1	1999-04-29
WO1999044987A1	1999-09-10
WO1997016444A1	1997-05-09
WO2000000472A1	2000-01-06

Foreign References:

DD298475A5	1992-02-27
US5827860A	1998-10-27
EP0671390A2	1995-09-13
US5773646A	1998-06-30
EP0902036A1	1999-03-17

Other References: