Title:
AMINO ACID-BASED CATIONIC LIPID CONTAINING UNSATURATED BONDS
Document Type and Number:
WIPO Patent Application WO/2023/232148
Kind Code:
A1
Abstract:
Provided in the present invention is a new amino acid-based cationic lipid containing unsaturated bonds, the structure of which is as shown in general formula (1), and the definitions of each symbol in the formula is consistent with those described herein. The raw materials of amino acids or amino acid derivatives used in the preparation process are simple and easy to obtain, and have the advantages of simplicity, safety and production cost saving. The amino acid-based cationic lipid containing unsaturated bonds of the present invention contains a tertiary amine structure derived from unsaturated hydrocarbyl tail chains and amino acid residues, and lipid nanoparticle (LNP) prepared therefrom has higher membrane fluidity to enhance the membrane fusion ability, which is beneficial to improving cellular uptake, thereby improving the delivery efficiency of the amino acid-based cationic lipid containing unsaturated bonds as a delivery material.
Inventors:
LIN MINGGUI (CN)
WENG WENGUI (CN)
LIU CHAO (CN)
WANG LINLIN (CN)
LIN SHENG (CN)
WANG AILAN (CN)
WEI GUOHUA (CN)
ZHU QI (CN)
WENG WENGUI (CN)
LIU CHAO (CN)
WANG LINLIN (CN)
LIN SHENG (CN)
WANG AILAN (CN)
WEI GUOHUA (CN)
ZHU QI (CN)
Application Number:
PCT/CN2023/098158
Publication Date:
December 07, 2023
Filing Date:
June 02, 2023
Export Citation:
Assignee:
XIAMEN SINOPEG BIOTECH CO LTD (CN)
International Classes:
C07C229/26; A61K9/127; A61K47/18; C07C227/18
Domestic Patent References:
| WO2018062413A1 | 2018-04-05 | |||
| WO2002072068A2 | 2002-09-19 |
Foreign References:
| CN107427531A | 2017-12-01 | |||
| CN111087317A | 2020-05-01 | |||
| CN104168887A | 2014-11-26 | |||
| RU2233834C2 | 2004-08-10 |
Other References:
TANG, FUXING ET AL.: "Synthesis of a single-tailed cationic lipid and investigation of its transfection", JOURNAL OF CONTROLLED RELEASE, vol. 62, 6 December 1999 (1999-12-06), pages 345 - 358, XP004363033, DOI: 10.1016/S0168-3659(99)00158-3
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