Title:
AMINO ACID CATIONIC LIPID
Document Type and Number:
WIPO Patent Application WO/2023/232147
Kind Code:
A1
Abstract:
The present invention provides a novel amino acid cationic lipid, having a structure as shown in general formula (1), the definition of symbols therein being consistent with that in the text. The amino acid cationic lipid is a lipid that is pharmaceutically acceptable, biodegradable, or highly biocompatible, and has the advantages of low toxicity, low immunogenicity, and high biocompatibility. Raw materials of an amino acid or amino acid derivative used in the preparation process are simple and easy to obtain, can be obtained naturally or by simply synthesizing, and have the advantages of being simple and safe and saving production costs. A degradable group can also be contained between an amino acid residue and a lipophilic tail chain of the novel amino acid cationic lipid of the present invention, and the presence of the degradable group enables lipid nanoparticles (LNPs) prepared therefrom to be degraded in a timely manner in an endosome, such that the problems in the prior art that the endosomal escape of drug molecules (such as nucleic acids) is hindered and drugs delivered into cells cannot work since LNPs prepared from a non-degradable lipid would accumulate in the endosome and acidify the endosomal environment are solved.
Inventors:
LIN SHENG (CN)
WENG WENGUI (CN)
LIU CHAO (CN)
WANG AILAN (CN)
WANG LINLIN (CN)
LIN MINGGUI (CN)
ZHU QI (CN)
WEI GUOHUA (CN)
WENG WENGUI (CN)
LIU CHAO (CN)
WANG AILAN (CN)
WANG LINLIN (CN)
LIN MINGGUI (CN)
ZHU QI (CN)
WEI GUOHUA (CN)
Application Number:
PCT/CN2023/098155
Publication Date:
December 07, 2023
Filing Date:
June 02, 2023
Export Citation:
Assignee:
XIAMEN SINOPEG BIOTECH CO LTD (CN)
International Classes:
C07C229/24; A61K9/127; A61K47/18; A61K48/00; C07C229/26; C07C229/28
Foreign References:
| CN104136419A | 2014-11-05 | |||
| CN101797210A | 2010-08-11 | |||
| CN113402405A | 2021-09-17 | |||
| CN102875405A | 2013-01-16 | |||
| FR2961100A1 | 2011-12-16 | |||
| FR2982485A1 | 2013-05-17 |
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