Title:
AMINO QUINAZOLINONE, AMINO ISOQUINOLONE DERIVATIVES AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/134921
Kind Code:
A1
Abstract:
Provided by the present invention are an amino quinazolinone and amino isoquinolone derivatives. It is verified by numerous experiments that the compounds provided by the present invention have good inhibiting effects on PI3Kα and PI3Kγ, most of the compounds have prominent inhibiting effect on PI3Kα, and show strong growth inhibiting effect on PIK3CA mutant tumor cells such as human breast cancer cell strain (MCF7). Therefore, the amino quinazolinone and amino isoquinolone derivatives according to the present invention can be applied in the preparation of anti-tumor and anti-inflammatory medicines, and can be used as PI3Kα inhibitors in the preparation of medicines for treatment of human or animal cell proliferation related tumors, the medicines comprising the derivatives any one or more of pharmaceutically acceptable salts and solvates thereof as well as pharmaceutically acceptable carriers. Formulas a and b for the compounds of the present invention are shown as below:
Inventors:
SHENG RONG (CN)
LI JIA (CN)
GU DONGYAN (CN)
ZHOU YUBO (CN)
WEI JUN (CN)
ZHANG MENGMENG (CN)
HU YONGZHOU (CN)
ZHANG KAIXIANG (CN)
LIU JIEYU (CN)
KAN WEIJUAN (CN)
LI JIA (CN)
GU DONGYAN (CN)
ZHOU YUBO (CN)
WEI JUN (CN)
ZHANG MENGMENG (CN)
HU YONGZHOU (CN)
ZHANG KAIXIANG (CN)
LIU JIEYU (CN)
KAN WEIJUAN (CN)
Application Number:
PCT/CN2019/122973
Publication Date:
July 02, 2020
Filing Date:
December 04, 2019
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
SHANGHAI INST MATERIA MEDICA CAS (CN)
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07D239/95; A61K31/506; A61K31/517; A61K31/519; A61K31/5377; A61P11/00; A61P11/06; A61P13/12; A61P17/06; A61P19/02; A61P19/08; A61P29/00; A61P35/00; A61P35/02; A61P37/08; C07D401/12; C07D403/12; C07D413/14; C07D417/12; C07D473/00; C07D491/056
Domestic Patent References:
| WO2012037204A1 | 2012-03-22 |
Foreign References:
| CN103946226A | 2014-07-23 | |||
| CN103998442A | 2014-08-20 | |||
| CN109516961A | 2019-03-26 | |||
| CN101965335A | 2011-02-02 | |||
| CN101965336A | 2011-02-02 |
Other References:
CHEMMEDCHEM, vol. 11, 2016, pages 1517 - 1530
See also references of EP 3904343A4
See also references of EP 3904343A4
Attorney, Agent or Firm:
HANGZHOU QIUSHI PATENT OFFICE CO.,LTD. (CN)
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