γ-AMINOBUTYRIC ACID SEMIHYDRATE CRYSTAL AND PREPARATION METHOD THEREFOR

WIPO Patent Application WO/2018/086053

A1

The present invention discloses a γ-aminobutyric acid semihydrate crystal. The formula of the crystal is C4H9NO2·0.5H2O. The present invention further discloses a preparation method for the γ-aminobutyric acid semihydrate crystal, wherein first a crude γ-aminobutyric acid is added to water to obtain a γ-aminobutyric acid suspension with an initial concentration of 1.2-2.0 g/mL; then the suspension is stirred under a constant temperature of 5-10°C for 6 to 12 hours, then the suspension is filtered and dried to obtain the γ-aminobutyric acid semihydrate crystal. The γ-aminobutyric acid semihydrate crystal of the present invention has good stability, does not readily absorb moisture or coalesce, and is convenient for further processing and use. The crystal has a large main particle size and a uniform particle size distribution, has a high bulk density and a good flowability, and has a purity of ≥ 99%. The preparation method for the γ-aminobutyric acid semihydrate crystal of the present invention is simple and feasible, and has short time consumption and high efficiency and low energy consumption, making it favorable for large-scale industrial production.

GONG JUNBO (CN)
GU QINQING (CN)
ZHAO KAIFEI (CN)
LI JIANGBO (CN)
HOU BAOHONG (CN)
YIN QIUXIANG (CN)
WANG JINGKANG (CN)
SUN YI (CN)
DU SHICHAO (CN)
PAN XIN (CN)
LIU ZHONGSHI (CN)

PCT/CN2016/105420

May 17, 2018

November 11, 2016

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NANTONG LICHENG BIOLOGICAL ENG CO LTD (CN)
UNIV TIANJIN (CN)

C07C227/42; C07C229/08

CN101160281A	2008-04-09
CN102242161A	2011-11-16

SCIHEAD IP LAW FIRM (CN)

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