ANILINE DERIVATIVE HAVING THE EFFECT OF INHIBITING NITROGEN MONOXIDE SYNTHASE

WIPO Patent Application WO/1996/018607

A1

A compound represented by general formula (1) or possible stereoisomers and optical isomers thereof, and medicinally acceptable salts of these compounds, wherein R1 represents SR6 or NHR7; R6 represents C1-C6 alkyl, etc.; R7 represents hydrogen, C1-C6 alkyl or nitro; R2 and R3 represent each hydrogen, C1-C6 alkyl, etc., R4 represents hydrogen, C1-C6 alkyl or an amidino group wherein the amino group may be substituted by alkyl or nitro; R5 represents hydrogen or C1-C6 alkyl; Y1, Y2, Y3 and Y4 represent each independently hydrogen, halogen, C1-C6 alkyl, etc., and n and m represent each an integer of 0 or 1. These compounds have a potent activity of inhibiting nitrogen monoxide synthases and are useful as a remedy for cerebrovascular disorder.

HONDA TOSHIO (JP)
MAKINO TOSHIHIKO (JP)
NAGAFUJI TOSHIAKI (JP)

PCT/JP1995/001135

June 20, 1996

June 07, 1995

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CHUGAI PHARMACEUTICAL CO LTD (JP)
HONDA TOSHIO (JP)
MAKINO TOSHIHIKO (JP)
NAGAFUJI TOSHIAKI (JP)

A61K31/155; A61K31/195; A61K31/21; C07D295/12; A61K31/215; A61K31/27; A61K31/275; A61K31/40; A61P3/00; A61P3/14; A61P9/00; A61P43/00; C07C57/30; C07C205/11; C07C205/12; C07C205/19; C07C205/37; C07C205/56; C07C211/52; C07C211/53; C07C271/10; C07C279/18; C07C279/30; C07C279/34; C07C279/36; C07C335/16; C07C335/20; C07C335/22; C07C335/32; C07C335/36; C07C381/14; C07D209/48; C07D295/135; (IPC1-7): C07C279/18; C07C335/32

WO1995009619A2

1995-04-13

JPS62158249A	1987-07-14
JPS5931757A	1984-02-20
JPS5297933A	1977-08-17
JPS5013391A	1975-02-12
JPS58194814A	1983-11-12
JPS58113149A	1983-07-05
JPH0614797A	1994-01-25
US3547619A	1970-12-15

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