Title:
ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY
Document Type and Number:
WIPO Patent Application WO/1996/018608
Kind Code:
A1
Abstract:
A compound represented by general formula (1),zor possible stereoisomers and optical isomers thereof, and medicinally acceptable salts of these, (wherein R1 represents SR6 or NR7R8; R6 represents C1-C6 alkyl, etc.; R7 represents hydrogen, C1-C6 alkyl or nitro; R8 represents hydrogen or C1-C6 alkyl; R2 and R3 represent each hydrogen, C1-C6 alkyl, etc.; R4 represents hydrogen, C1-C6 alkyl or amidino wherein the amine moiety may be substituted by alkyl or nitro; R5 represents hydrogen or C1-C6 alkyl; Y1, Y2, Y3 and Y4 may be the same or different and each represents hydrogen, halogeno, C1-C6 alkoxy, etc.; and n and m represent each an integer of 0 or 1). The compound has a potent nitrogen monoxide synthase inhibitory activity and is useful as a remedy for cerebrovascular disorder.
Inventors:
HONDA TOSHIO (JP)
MAKINO TOSHIHIKO (JP)
NAGAFUJI TOSHIAKI (JP)
KITOH YASUSHI (JP)
KIMURA NOBUAKI (JP)
MAKINO TOSHIHIKO (JP)
NAGAFUJI TOSHIAKI (JP)
KITOH YASUSHI (JP)
KIMURA NOBUAKI (JP)
Application Number:
PCT/JP1995/002540
Publication Date:
June 20, 1996
Filing Date:
December 12, 1995
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
HONDA TOSHIO (JP)
MAKINO TOSHIHIKO (JP)
NAGAFUJI TOSHIAKI (JP)
KITOH YASUSHI (JP)
KIMURA NOBUAKI (JP)
HONDA TOSHIO (JP)
MAKINO TOSHIHIKO (JP)
NAGAFUJI TOSHIAKI (JP)
KITOH YASUSHI (JP)
KIMURA NOBUAKI (JP)
International Classes:
A61K31/155; A61K31/195; A61K31/21; A61K31/215; A61K31/27; A61K31/275; A61K31/40; A61P3/00; A61P3/14; A61P9/00; C07D295/12; A61P43/00; C07C57/30; C07C205/11; C07C205/12; C07C205/19; C07C205/37; C07C205/56; C07C211/52; C07C211/53; C07C271/10; C07C279/18; C07C279/30; C07C279/34; C07C279/36; C07C335/16; C07C335/20; C07C335/22; C07C335/32; C07C335/36; C07C381/14; C07D209/48; C07D295/135; (IPC1-7): C07C279/18; C07C279/30; C07C335/16; C07D295/135; A61K31/155; A61K31/27; A61K31/275; A61K31/195; A61K31/21; A61K31/40
Domestic Patent References:
| WO1995000505A1 | 1995-01-05 | |||
| WO1995009619A2 | 1995-04-13 |
Foreign References:
| JPS5931757A | 1984-02-20 | |||
| US4156734A | 1979-05-29 | |||
| JPS5299227A | 1977-08-19 |
Other References:
BRANDISH D.E., JOURNAL OF CHEMICAL SOCIETY, PERKIN TRANSACTIONS, no. 18, 1977, pages 2025 - 2030
WEINSTOCK J., JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, 1987, pages 1166 - 1176
See also references of EP 0798292A4
WEINSTOCK J., JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, 1987, pages 1166 - 1176
See also references of EP 0798292A4
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