Title:
ANTI-CD200R1 ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2023/222068
Kind Code:
A1
Abstract:
Disclosed herein are antibodies that binds to CD200R1 and antigen-binding fragments thereof, as well as uses thereof, nucleic acids encoding the antibodies and antigen-binding fragments, vectors comprising the nucleic acids, and host cell comprising the nucleic acids or the vectors. Also disclosed are pharmaceutical compositions and conjugates comprising the antibodies, and therapeutic methods for using the antibodies.
Inventors:
BAO MUSHENG (CN)
WANG YUHUA (CN)
DU QIUMEI (CN)
PAN HONGJIE (CN)
BAJPAI GEETIKA (CN)
HE JINQIU (CN)
LI YAN (CN)
CHEN QINGFANG (CN)
WANG YONGQIANG (CN)
JIA XINGXING (CN)
CHEN FEI (CN)
WANG YOUHONG (CN)
WANG YUHUA (CN)
DU QIUMEI (CN)
PAN HONGJIE (CN)
BAJPAI GEETIKA (CN)
HE JINQIU (CN)
LI YAN (CN)
CHEN QINGFANG (CN)
WANG YONGQIANG (CN)
JIA XINGXING (CN)
CHEN FEI (CN)
WANG YOUHONG (CN)
Application Number:
PCT/CN2023/094951
Publication Date:
November 23, 2023
Filing Date:
May 18, 2023
Export Citation:
Assignee:
HARBOUR BIOMED SHANGHAI CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00; C12N15/13
Domestic Patent References:
| WO2021243204A1 | 2021-12-02 | |||
| WO2015057906A1 | 2015-04-23 | |||
| WO2021096753A1 | 2021-05-20 | |||
| WO2008079352A2 | 2008-07-03 |
Foreign References:
| US20200232990A1 | 2020-07-23 |
Other References:
GORCZYNSKI REGINALD M., LEE LYDIA, BOUDAKOV IVO: "Augmented Induction of CD4+CD25+ Treg using Monoclonal Antibodies to CD200R : ", TRANSPLANTATION, WILLIAMS AND WILKINS, GB, vol. 79, no. 9, 1 May 2005 (2005-05-01), GB , pages 1180 - 1183, XP093108124, ISSN: 0041-1337, DOI: 10.1097/01.TP.0000152118.51622.F9
GORCZYNSKI REGINALD M., CHEN ZHIQI, KAI YU, WONG SIMON, LEE LYDIA: "INDUCTION OF TOLERANCE-INDUCING ANTIGEN-PRESENTING CELLS IN BONE MARROW CULTURES IN VITRO USING MONOCLONAL ANTIBODIES TO CD200R : ", TRANSPLANTATION, WILLIAMS AND WILKINS, GB, vol. 77, no. 8, 1 April 2004 (2004-04-01), GB , pages 1138 - 1144, XP093108160, ISSN: 0041-1337, DOI: 10.1097/01.TP.0000121773.18476.1C
LI, Y. ET AL.: "Aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity", ARTHRITIS RESEARCH & THERAPY, vol. 14, 23 May 2012 (2012-05-23), XP021096219, DOI: 10.1186/ar3853
GORCZYNSKI REGINALD M., CHEN ZHIQI, KAI YU, WONG SIMON, LEE LYDIA: "INDUCTION OF TOLERANCE-INDUCING ANTIGEN-PRESENTING CELLS IN BONE MARROW CULTURES IN VITRO USING MONOCLONAL ANTIBODIES TO CD200R : ", TRANSPLANTATION, WILLIAMS AND WILKINS, GB, vol. 77, no. 8, 1 April 2004 (2004-04-01), GB , pages 1138 - 1144, XP093108160, ISSN: 0041-1337, DOI: 10.1097/01.TP.0000121773.18476.1C
LI, Y. ET AL.: "Aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity", ARTHRITIS RESEARCH & THERAPY, vol. 14, 23 May 2012 (2012-05-23), XP021096219, DOI: 10.1186/ar3853
Attorney, Agent or Firm:
LIU , SHEN & ASSOCIATES (CN)
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