Title:
ANTI-CD40 ANTIBODY, ANTIGEN-BINDING FRAGMENT AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/274201
Kind Code:
A1
Abstract:
Provided are an anti-CD40 antibody, an antigen-binding fragment and a medical use thereof, as well as a pharmaceutical composition containing the anti-CD40 antibody or antigen-binding fragment thereof, and a method for treating and preventing disease, in particular a method for treating autoimmune disease.
Inventors:
LIN YUAN (CN)
SU LU (CN)
LIN KAN (CN)
LIAO CHENG (CN)
SU LU (CN)
LIN KAN (CN)
LIAO CHENG (CN)
Application Number:
PCT/CN2022/101780
Publication Date:
January 05, 2023
Filing Date:
June 28, 2022
Export Citation:
Assignee:
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
SHANGHAI SHENGDI PHARMACEUTICAL CO LTD (CN)
SHANGHAI SHENGDI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K16/28; A61K39/395
Domestic Patent References:
| WO2020006347A1 | 2020-01-02 | |||
| WO2017059196A2 | 2017-04-06 | |||
| WO2018088850A2 | 2018-05-17 | |||
| WO2009040562A1 | 2009-04-02 | |||
| WO2010035012A1 | 2010-04-01 | |||
| WO2005003169A2 | 2005-01-13 | |||
| WO2005003170A2 | 2005-01-13 | |||
| WO2005003171A2 | 2005-01-13 | |||
| WO1992022583A2 | 1992-12-23 | |||
| WO2005113605A1 | 2005-12-01 | |||
| WO2003048731A2 | 2003-06-12 |
Foreign References:
| CN103209996A | 2013-07-17 | |||
| CN109912717A | 2019-06-21 | |||
| CN103450360A | 2013-12-18 | |||
| CN1522264A | 2004-08-18 | |||
| CN103930442A | 2014-07-16 | |||
| CN202110722124A | 2021-06-28 | |||
| US8277810B2 | 2012-10-02 |
Other References:
ZHANG JIE, LI LING-LING , ZHAN YU , LIU DAN-DAN , PENG BAO-ZHEN , LIU HAN-SHAO ,ZHSNG XIAO-REN: "The screen and functional study of CD 40 monoclonal antibody", SHANGHAI J.OF IMMUNOLOGY, vol. 37, no. 5, 30 September 2017 (2017-09-30), CN , pages 353 - 359, XP055851587, ISSN: 1001-2478
PERPER STUART J., WESTMORELAND SUSAN V., KARMAN JOZSEF, TWOMEY RACHEL, SEAGAL JANE, WANG RUI, MCRAE BRADFORD L., CLARKE STEPHEN H.: "Treatment with a CD40 Antagonist Antibody Reverses Severe Proteinuria and Loss of Saliva Production and Restores Glomerular Morphology in Murine Systemic Lupus Erythematosus", THE JOURNAL OF IMMUNOLOGY, vol. 203, no. 1, 1 July 2019 (2019-07-01), US , pages 58 - 75, XP093019226, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1900043
J. BIOL. CHEM, vol. 243, 1968, pages 3558
LEDBETTER ET AL., J. IMMUNOL., vol. 138, 1987, pages 788 - 785
STAMENKOVIC ET AL., EMBO J., vol. 8, 1989, pages 1403
JOHNSONWU, NUCLEIC ACIDS RES., vol. 28, 2000, pages 214 - 8
CHOTHIA ET AL., J. MOL. BIOL., vol. 196, 1986, pages 901 - 17
CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 877 - 83
MARTIN ET AL., PROC NATL ACAD SCI (USA, vol. 86, 1989, pages 9268 - 9272
SAMUDRALA ET AL.: "Ab Initio Protein Structure Prediction Using a Combined Hierarchical Approach", PROTEINS, STRUCTURE, FUNCTION AND GENETICS, 1999, pages 194 - 198, XP001146416
MACCALLUM ET AL., J. MOL. BIOL., vol. 5, 1996, pages 732 - 45
MAKABE ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 283, 2008, pages 1156 - 1166
HOLLIGERHUDSON, NATURE BIOTECH., vol. 23, no. 9, 2005, pages 1126 - 1136
ADAIRLAWSON, DRUG DESIGN REVIEWS-ONLINE, vol. 2, no. 3, 2005, pages 209 - 217
VERMA ET AL., JOURNAL OF IMMUNOLOGICAL METHODS, vol. 216, 1998, pages 165 - 181
CACECI ET AL., BYTE, vol. 9, 1984, pages 340 - 362
WONGLOHMAN, PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5428 - 5432
SAMBROOK ET AL.: "Current Protocols in Molecular Biology", GREENE PUBLISHING ASSOCIATION, WILEY INTERSCIENCE
PERPER STUART J., WESTMORELAND SUSAN V., KARMAN JOZSEF, TWOMEY RACHEL, SEAGAL JANE, WANG RUI, MCRAE BRADFORD L., CLARKE STEPHEN H.: "Treatment with a CD40 Antagonist Antibody Reverses Severe Proteinuria and Loss of Saliva Production and Restores Glomerular Morphology in Murine Systemic Lupus Erythematosus", THE JOURNAL OF IMMUNOLOGY, vol. 203, no. 1, 1 July 2019 (2019-07-01), US , pages 58 - 75, XP093019226, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1900043
J. BIOL. CHEM, vol. 243, 1968, pages 3558
LEDBETTER ET AL., J. IMMUNOL., vol. 138, 1987, pages 788 - 785
STAMENKOVIC ET AL., EMBO J., vol. 8, 1989, pages 1403
JOHNSONWU, NUCLEIC ACIDS RES., vol. 28, 2000, pages 214 - 8
CHOTHIA ET AL., J. MOL. BIOL., vol. 196, 1986, pages 901 - 17
CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 877 - 83
MARTIN ET AL., PROC NATL ACAD SCI (USA, vol. 86, 1989, pages 9268 - 9272
SAMUDRALA ET AL.: "Ab Initio Protein Structure Prediction Using a Combined Hierarchical Approach", PROTEINS, STRUCTURE, FUNCTION AND GENETICS, 1999, pages 194 - 198, XP001146416
MACCALLUM ET AL., J. MOL. BIOL., vol. 5, 1996, pages 732 - 45
MAKABE ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 283, 2008, pages 1156 - 1166
HOLLIGERHUDSON, NATURE BIOTECH., vol. 23, no. 9, 2005, pages 1126 - 1136
ADAIRLAWSON, DRUG DESIGN REVIEWS-ONLINE, vol. 2, no. 3, 2005, pages 209 - 217
VERMA ET AL., JOURNAL OF IMMUNOLOGICAL METHODS, vol. 216, 1998, pages 165 - 181
CACECI ET AL., BYTE, vol. 9, 1984, pages 340 - 362
WONGLOHMAN, PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5428 - 5432
SAMBROOK ET AL.: "Current Protocols in Molecular Biology", GREENE PUBLISHING ASSOCIATION, WILEY INTERSCIENCE
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
Download PDF: