ANTI-DDR2 ANTIBODIES AND USES THEREOF - CHUGAI PHARMACEUTICAL CO LTD

Title:

ANTI-DDR2 ANTIBODIES AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2022/255440

Kind Code:

A1

Abstract:

The invention provides anti-DDR2 antibodies that binds to DDR2, and methods of using the same. The invention further provides isolated nucleic acids encoding the anti-DDR2 antibodies, host cells comprising the same, and methods of producing the anti-DDR2 antibodies. The invention further provides use of the anti-DDR2 antibodies in the manufacture of a medicament.

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Inventors:

TAKAHASHI NORIYUKI (SG)
KANAMORI MASAKAZU (JP)
YANG BO (SG)

Application Number:

PCT/JP2022/022441

Publication Date:

December 08, 2022

Filing Date:

June 02, 2022

Export Citation:

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Assignee:

CHUGAI PHARMACEUTICAL CO LTD (JP)

International Classes:

C07K16/28; A61K39/395; A61P43/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13

Domestic Patent References:

WO2013034933A1

2013-03-14

Foreign References:

US20140186342A1	2014-07-03
KR20150061285A	2015-06-04

Other References:

USHAKUMARY MEREENA GEORGE, WANG MINGYI, V HARIKRISHNAN, TITUS ALLEN SAM, ZHANG JING, LIU LIJUAN, MONTICONE ROBERT, WANG YUSHI, MAT: "Discoidin domain Receptor 2: A determinant of metabolic syndrome-associated arterial fibrosis in non-human primates", PLOS ONE, vol. 14, no. 12, 5 December 2019 (2019-12-05), pages 1 - 10, XP093009321, DOI: 10.1371/journal.pone.0225911
CARAFOLI FEDERICO; HOHENESTER ERHARD: "Collagen recognition and transmembrane signalling by discoidin domain receptors", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - PROTEINS & PROTEOMICS, vol. 1834, no. 10, 2 November 2012 (2012-11-02), Netherlands , pages 2187 - 2194, XP028713556, ISSN: 1570-9639, DOI: 10.1016/j.bbapap.2012.10.014