Title:
ANTI-INFECTIVE AGENTS USEFUL AGAINST MULTIDRUG-RESISTANT STRAINS OF BACTERIA
Document Type and Number:
WIPO Patent Application WO2001063539
Kind Code:
A3
Abstract:
The invention relates to novel methods for using macrolide anti-infective agents. The macrolide anti-infective agents demonstrate antibacterial activity against multi-drug resistant strains of bacteria and, in particular, methicillin-resistant Staphylococcus aureus (MRSA). Methods for inhibiting the activity of multi-drug resistant bacterial organisms and methods for treating a bacterial infection caused by such organisms are described herein.
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Inventors:
MA ZHENKUN
NEMOTO PETER A
ZHANG SOUMING
YONG HONG
OR YAT SUN
NEMOTO PETER A
ZHANG SOUMING
YONG HONG
OR YAT SUN
Application Number:
PCT/US2001/006006
Publication Date:
March 06, 2003
Filing Date:
February 23, 2001
Export Citation:
Assignee:
ABBOTT LAB (US)
International Classes:
A61K31/335; A61K31/7048; A61P31/04; C07H17/08; (IPC1-7): C07H17/08; A61K31/7048; A61P31/04
Domestic Patent References:
| WO1997042204A1 | 1997-11-13 |
Foreign References:
| EP0194833A2 | 1986-09-17 | |||
| EP0487411A1 | 1992-05-27 | |||
| EP1167375A1 | 2002-01-02 |
Other References:
SCHEMPP C M ET AL: "Antibacterial activity of hyperforin from St John's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria", LANCET, XX, XX, vol. 353, no. 9170, 16 June 1999 (1999-06-16), pages 2129, XP004266529, ISSN: 0140-6736
AGOURIDAS C ET AL: "SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF KETOLIDES (6-O-METHYL-3-OXOERYTHROMYCIN DERIVATIVES): A NEW CLASS OF ANTIBACTERIALS HIGHLY POTENT AGAINST MACROLIDE-RESISTANT AND -SUSCEPTIBLE RESPIRATORY PATHOGENS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 21, no. 41, 8 October 1998 (1998-10-08), pages 4080 - 4100, XP001068954, ISSN: 0022-2623
BERTHO, GILDAS ET AL: "Solution conformation of methylated macrolide antibiotics roxithromycin and erythromycin using NMR and molecular modeling. Ribosome-bound conformation determined by TRNOE and formation of cytochrome P450-metabolite complex", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (1998), 22(2), 103-127, XP002219406
KAWASHIMA, YUTAKA ET AL: "Structure-activity relationship study of 6-O-methylerythromycin 9-O-substituted oxime derivatives", CHEMICAL & PHARMACEUTICAL BULLETIN (1994), 42(5), 1088-95, XP002219407
DATABASE WPI Derwent World Patents Index; AN 2000-672675, XP002219408, "New erythromycin derivatives are antimicrobial agents active against e.g. Mycobacterium avium complex"
AGOURIDAS C ET AL: "SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF KETOLIDES (6-O-METHYL-3-OXOERYTHROMYCIN DERIVATIVES): A NEW CLASS OF ANTIBACTERIALS HIGHLY POTENT AGAINST MACROLIDE-RESISTANT AND -SUSCEPTIBLE RESPIRATORY PATHOGENS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 21, no. 41, 8 October 1998 (1998-10-08), pages 4080 - 4100, XP001068954, ISSN: 0022-2623
BERTHO, GILDAS ET AL: "Solution conformation of methylated macrolide antibiotics roxithromycin and erythromycin using NMR and molecular modeling. Ribosome-bound conformation determined by TRNOE and formation of cytochrome P450-metabolite complex", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (1998), 22(2), 103-127, XP002219406
KAWASHIMA, YUTAKA ET AL: "Structure-activity relationship study of 6-O-methylerythromycin 9-O-substituted oxime derivatives", CHEMICAL & PHARMACEUTICAL BULLETIN (1994), 42(5), 1088-95, XP002219407
DATABASE WPI Derwent World Patents Index; AN 2000-672675, XP002219408, "New erythromycin derivatives are antimicrobial agents active against e.g. Mycobacterium avium complex"
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