Title:
ANTI-INFLAMMATORY AGENT
Document Type and Number:
WIPO Patent Application WO2003024474
Kind Code:
A3
Abstract:
This invention relates to the use of a phosphorylcholine-containing glycoprotein in the treatment or prophylaxis of diseases associated with inflammation. In particular, the present invention relates to the use of ES-62 for the treatment or prophylaxis of autoimmune diseases associated with abnormal inflammation, such as rheumatoid arthritis.
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Inventors:
HARNETT WILLIAM (GB)
HARNETT MARGARET B (GB)
MCINNES IAIN (GB)
HARNETT MARGARET B (GB)
MCINNES IAIN (GB)
Application Number:
PCT/GB2002/004310
Publication Date:
August 21, 2003
Filing Date:
September 20, 2002
Export Citation:
Assignee:
UNIV STRATHCLYDE (GB)
UNIV GLASGOW (GB)
HARNETT WILLIAM (GB)
HARNETT MARGARET B (GB)
MCINNES IAIN (GB)
UNIV GLASGOW (GB)
HARNETT WILLIAM (GB)
HARNETT MARGARET B (GB)
MCINNES IAIN (GB)
International Classes:
A61K38/17; A61P1/04; A61P1/16; A61P3/10; A61P11/00; A61P17/04; A61P19/02; A61P25/00; A61P29/00; A61P35/00; A61P37/02; C07K14/435; (IPC1-7): A61K38/14; A61K39/00; A61P29/00; A61P37/02
Other References:
GOODRIDGE H. S. ET AL: "Modulation of macrophage Cytokine Production by ES-62, a secreted product of the Filarial Nematode Acanthocheilonema viteae", THE JOURNAL OF IMMUNOLOGY, vol. 167, 2001, pages 940 - 945, XP002243871
HARNETT W. ET AL: "Modulation of the host immune system by phosphorylcholine-containing glycoproteins secreted by parasitic filarial nematodes", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1539, 2001, pages 7 - 15, XP002243872
WHELAN M. ET AL: "A Filarial Nematode-Secreted product Signals Dendritic Cells to Acquire a Phenotype That Drives Development of Th2 Cells", THE JOURNAL OF IMMUNOLOGY, vol. 164, 2000, pages 6453 - 6460, XP002243873
HARNETT, WILLIAM ET AL: "Immunomodulation by filarial nematode phosphorylcholine-containing glycoproteins", 2001, PARASITIC NEMATODES (2001), 399-414. EDITOR(S): KENNEDY, MALCOLM W.;HARNETT, WILLIAM. PUBLISHER: CABI PUBLISHING, WALLINGFORD, UK., XP001152690
HARNETT, WILLIAM ET AL: "Immunomodulatory properties of a phosphorylcholine-containing secreted filarial glycoprotein", PARASITE IMMUNOLOGY (1999), 21(12), 601-608, 1999, XP002243874
HARNETT W. ET AL: "Modulation of the host immune system by phosphorylcholine-containing glycoproteins secreted by parasitic filarial nematodes", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1539, 2001, pages 7 - 15, XP002243872
WHELAN M. ET AL: "A Filarial Nematode-Secreted product Signals Dendritic Cells to Acquire a Phenotype That Drives Development of Th2 Cells", THE JOURNAL OF IMMUNOLOGY, vol. 164, 2000, pages 6453 - 6460, XP002243873
HARNETT, WILLIAM ET AL: "Immunomodulation by filarial nematode phosphorylcholine-containing glycoproteins", 2001, PARASITIC NEMATODES (2001), 399-414. EDITOR(S): KENNEDY, MALCOLM W.;HARNETT, WILLIAM. PUBLISHER: CABI PUBLISHING, WALLINGFORD, UK., XP001152690
HARNETT, WILLIAM ET AL: "Immunomodulatory properties of a phosphorylcholine-containing secreted filarial glycoprotein", PARASITE IMMUNOLOGY (1999), 21(12), 601-608, 1999, XP002243874
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