Title:
RETINOID RECEPTOR PAN-ANTAGONISTS FOR STIMULATING CHONDROGENESIS
Document Type and Number:
WIPO Patent Application WO2003024473
Kind Code:
A3
Abstract:
The invention relates to methods and compositions for inducing or enhancing chondrogenesis in vivo and/or ex vivo. More specifically, the invention is directed to the use of RAR pan-antagonist compositions for the treatment, repair and engineering of cartilage.
Inventors:
UNDERHILL TULLEY MICHAEL (CA)
WESTON ANDREA D (CA)
WESTON ANDREA D (CA)
Application Number:
PCT/CA2002/001421
Publication Date:
August 07, 2003
Filing Date:
September 17, 2002
Export Citation:
Assignee:
UNIV WESTERN ONTARIO (CA)
UNDERHILL TULLEY MICHAEL (CA)
WESTON ANDREA D (CA)
UNDERHILL TULLEY MICHAEL (CA)
WESTON ANDREA D (CA)
International Classes:
A61K31/00; A61K31/353; A61K31/382; A61K31/56; A61K31/66; A61K45/06; A61L27/22; A61L27/38; A61L27/54; A61P19/00; C12N5/077; (IPC1-7): A61K31/00; C12N5/06; C12N5/08; A61L27/28; A61K35/32; A61P19/00
Domestic Patent References:
| WO2000030635A1 | 2000-06-02 | |||
| WO2001043732A2 | 2001-06-21 |
Other References:
M. SCHAPIRA ET AL.: "Rational discovery of novel nuclear hormone receptor antagonists", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 97, no. 3, 1 February 2000 (2000-02-01), pages 1008 - 1013, XP002170486, ISSN: 0027-8424
A.D. WESTON ET AL.: "Requirement for RAR-mediated gene expression in skeletal progenitor differentiation.", THE JOURNAL OF CELL BIOLOGY, vol. 158, no. 1, 8 July 2002 (2002-07-08), pages 39 - 51, XP002244028
A.D. WESTON ET AL.: "Regulation of skeletal progenitor differentiation by the BMP and retinoid signaling pathways.", THE JOURNAL OF CELL BIOLOGY, vol. 148, no. 4, 21 February 2000 (2000-02-21), pages 679 - 690, XP002244029
I. SEKIYA ET AL.: "Transcriptional suppression of Sox9 expression in chondrocytes by retinoic acid.", JOURNAL OF CELLULAR BIOCHEMISTRY SUPPLEMENT, vol. 36, 15 March 2001 (2001-03-15), pages 71 - 78, XP002244030
A.D. WESTON ET AL.: "Requirement for RAR-mediated gene expression in skeletal progenitor differentiation.", THE JOURNAL OF CELL BIOLOGY, vol. 158, no. 1, 8 July 2002 (2002-07-08), pages 39 - 51, XP002244028
A.D. WESTON ET AL.: "Regulation of skeletal progenitor differentiation by the BMP and retinoid signaling pathways.", THE JOURNAL OF CELL BIOLOGY, vol. 148, no. 4, 21 February 2000 (2000-02-21), pages 679 - 690, XP002244029
I. SEKIYA ET AL.: "Transcriptional suppression of Sox9 expression in chondrocytes by retinoic acid.", JOURNAL OF CELLULAR BIOCHEMISTRY SUPPLEMENT, vol. 36, 15 March 2001 (2001-03-15), pages 71 - 78, XP002244030
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