Title:
ANTI-INFLAMMATORY AGENTS AND METHODS OF THEIR USE
Document Type and Number:
WIPO Patent Application WO2004062621
Kind Code:
A3
Abstract:
The present disclosure provides compositions and methods for reducing or inhibiting vascular inflammation, for example inflammation resulting from unstable blood flow conditions such as oscillatory shear. Representative compositions include an antagonist of BMPs, for example BMP4, or BMP receptors, for example BMPR-I and/or BMPR-II, in an amount sufficient to for inhibiting or reducing vascular inflammation by interfering with binding of bone morphogenic protein or a fragment thereof to bone morphogenic protein receptors. Exemplary BMP antagonists include polypeptides having an eight-, nine-, or ten-membered ring cystine knot structure. Representative BMP antagonists include, but are not limited to the CAN family of proteins, the chordin family that includes chordin and ventroptin, and noggin.
Inventors:
JO HANJOONG (US)
Application Number:
PCT/US2004/000759
Publication Date:
October 12, 2006
Filing Date:
January 13, 2004
Export Citation:
Assignee:
GEORGIA TECH RES INST (US)
JO HANJOONG (US)
JO HANJOONG (US)
International Classes:
A61K38/17; A61K38/18; A61K; (IPC1-7): A61K38/00
Domestic Patent References:
| WO2000056879A1 | 2000-09-28 | |||
| WO1998049296A1 | 1998-11-05 |
Other References:
SCHMITT J.M. ET AL: "Bone Morphogenetic Proteins: An Update on Basic Biology and Clinical Relevance", J. ORTHOPAEDIC RES., vol. 17, 1999, pages 269 - 278, XP001106344
MOYAD M.A.: "An Introduction to Aspirin, NSAIDSs, and COX-2 Inhibitors for the Primary Prevention of Cardiovascular Events and Cancer and Their Potential Preventive Role in Bladder Carcinogenesis: Part I", SEMIN. UROL. ONCOL., vol. 19, 2001, pages 294 - 305, XP009009934
VIRMANI R. ET AL: "Pathology of in-stent restenosis", CURR. OPIN. LIPIDOL., vol. 10, 1999, pages 499 - 506, XP008074067
MOYAD M.A.: "An Introduction to Aspirin, NSAIDSs, and COX-2 Inhibitors for the Primary Prevention of Cardiovascular Events and Cancer and Their Potential Preventive Role in Bladder Carcinogenesis: Part I", SEMIN. UROL. ONCOL., vol. 19, 2001, pages 294 - 305, XP009009934
VIRMANI R. ET AL: "Pathology of in-stent restenosis", CURR. OPIN. LIPIDOL., vol. 10, 1999, pages 499 - 506, XP008074067
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