PROCESS OF PREPARING ESTERS AND ETHERS OF PROBUCOL AND DERIVATIVES THEREOF

Title:

PROCESS OF PREPARING ESTERS AND ETHERS OF PROBUCOL AND DERIVATIVES THEREOF

Document Type and Number:

WIPO Patent Application WO2004062622

Kind Code:

A3

Abstract:

A probucol or a probucol derivative can be efficiently converted to a monoester or monoether of probucol by reacting the free hydroxyl-containing probucol or a derivative thereof (by which is meant a probucol compound with at least one substituent that is different from that on the parent probucol molecule but which maintains the two free hydroxyl groups) with a Grignard reagent or a lithium reagent that produces a magnesium bromide or lithium salt of probucol or the probucol derivative. The probucol compound anion anion is then reacted with an ester or ether forming compound.

Inventors:

WEINGARTEN M DAVID (US)
SIKORSKI JAMES A (US)

Application Number:

PCT/US2004/000805

Publication Date:

December 02, 2004

Filing Date:

January 13, 2004

Export Citation:

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Assignee:

ATHEROGENICS INC (US)
WEINGARTEN M DAVID (US)
SIKORSKI JAMES A (US)

International Classes:

C07C319/20; C07C323/20; (IPC1-7): C07C9/00

Foreign References:

US6323359B1

2001-11-27

Other References: