Title:
ANTI-PD-L1 ANTIBODY FOR DETECTING PD-L1
Document Type and Number:
WIPO Patent Application WO/2024/048418
Kind Code:
A1
Abstract:
Provided is a diagnostic antibody that is capable of detecting PD-L1 in tumors for novel therapies for feline tumors targeting PD-1/PD-L1. The anti-PD-L1 antibody contains: (a) an L-chain having CDR1 that has the amino acid sequence ESVDSYGNSF (SEQ ID NO: 1), CDR2 that has the amino acid sequence RAS, and CDR3 that has the amino acid sequence QQSNEDPRT (SEQ ID NO: 2); and (b) an H-chain having CDR1 that has the amino acid sequence GFTFSSYG (SEQ ID NO: 3), CDR2 that has the amino acid sequence ISNGGTYT (SEQ ID NO: 4), and CDR3 that has the amino acid sequence ARLGYGSLNWYFDV (SEQ ID NO: 5). A composition for detecting PD-L1 that contains the anti-PD-L1 antibody as an active ingredient. Also provided is a method for producing the anti-PD-L1 antibody.
Inventors:
KONNAI SATORU (JP)
MAEKAWA NAOYA (JP)
OKAGAWA TOMOHIRO (JP)
OHASHI KAZUHIKO (JP)
MURATA SHIRO (JP)
SUZUKI YASUHIKO (JP)
MAEKAWA NAOYA (JP)
OKAGAWA TOMOHIRO (JP)
OHASHI KAZUHIKO (JP)
MURATA SHIRO (JP)
SUZUKI YASUHIKO (JP)
Application Number:
PCT/JP2023/030546
Publication Date:
March 07, 2024
Filing Date:
August 24, 2023
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
C12N15/13; C07K14/705; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12N15/63; C12P21/08; G01N33/574
Foreign References:
| JP2017518366A | 2017-07-06 | |||
| JP2021517472A | 2021-07-26 |
Other References:
FOLKL, A. ; WEN, X. ; KUCZYNSKI, E. ; CLARK, M.E. ; BIENZLE, D.: "Feline programmed death and its ligand: Characterization and changes with feline immunodeficiency virus infection", VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 134, no. 1-2, 15 March 2010 (2010-03-15), AMSTERDAM, NL, pages 107 - 114, XP026892592, ISSN: 0165-2427, DOI: 10.1016/j.vetimm.2009.10.019
Attorney, Agent or Firm:
MAYAMA, Setsuko et al. (JP)
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