Title:
ANTI-PEG ANTIBODY BINDING MATERIAL AND METHOD FOR DETECTING ANTI-PEG ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2023/166944
Kind Code:
A1
Abstract:
Provided is an anti-PEG antibody binding material that makes it possible to detect a methoxy-terminated PEG-selective anti-PEG antibody. An anti-PEG antibody binding material according to an embodiment of the present invention contains cellulose oligomers represented by general formula (1), and can bind to a methoxy-terminated PEG-selective anti-PEG antibody. In formula (1), n signifies the average degree of polymerization and represents a number of 6-16, and m represents an integer of 1-16.
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Inventors:
SERIZAWA TAKESHI (JP)
SAWADA TOSHIKI (JP)
MURASE RINA (JP)
NISHIURA MASAHITO (JP)
SAWADA TOSHIKI (JP)
MURASE RINA (JP)
NISHIURA MASAHITO (JP)
Application Number:
PCT/JP2023/004480
Publication Date:
September 07, 2023
Filing Date:
February 10, 2023
Export Citation:
Assignee:
TOKYO INST TECH (JP)
DKS CO LTD (JP)
DKS CO LTD (JP)
International Classes:
G01N33/532; G01N33/53; G01N33/536
Foreign References:
| JP2012533064A | 2012-12-20 | |||
| JP2021012089A | 2021-02-04 |
Other References:
BIVI NICOLETTA; SWEARINGEN CRAIG A.; SHOCKLEY TRAVIS E.; SLOAN JOHN H.; POTTANAT THOMAS G.; CARTER QUINCY LASHA; HODSDON MICHAEL E: "Development and validation of a novel immunogenicity assay to detect anti-drug and anti-PEG antibodies simultaneously with high sensitivity", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM., NL, vol. 486, 9 September 2020 (2020-09-09), NL , XP086281182, ISSN: 0022-1759, DOI: 10.1016/j.jim.2020.112856
EHLINGER CHRISTOPHER; SPEAR NATHAN; DODDAREDDY RAJITHA; SHANKAR GOPI; SCHANTZ ALLEN: "A generic method for the detection of polyethylene glycol specific IgG and IgM antibodies in human serum", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM., NL, vol. 474, 12 October 2019 (2019-10-12), NL , XP085892607, ISSN: 0022-1759, DOI: 10.1016/j.jim.2019.112669
JONATHAN K. ARMSTRONG; GEORG HEMPEL; SUSANNE KOLING; LINDA S. CHAN; TIMOTHY FISHER; HERBERT J. MEISELMAN; GEORGE GARRATTY: "Antibody against poly(ethylene glycol) adversely affects PEG‐asparaginase therapy in acute lymphoblastic leukemia patients", CANCER, AMERICAN CANCER SOCIETY , PHILADELPHIA , PA, US, vol. 110, no. 1, 21 May 2007 (2007-05-21), US , pages 103 - 111, XP071175423, ISSN: 0008-543X, DOI: 10.1002/cncr.22739
EHLINGER CHRISTOPHER; SPEAR NATHAN; DODDAREDDY RAJITHA; SHANKAR GOPI; SCHANTZ ALLEN: "A generic method for the detection of polyethylene glycol specific IgG and IgM antibodies in human serum", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM., NL, vol. 474, 12 October 2019 (2019-10-12), NL , XP085892607, ISSN: 0022-1759, DOI: 10.1016/j.jim.2019.112669
JONATHAN K. ARMSTRONG; GEORG HEMPEL; SUSANNE KOLING; LINDA S. CHAN; TIMOTHY FISHER; HERBERT J. MEISELMAN; GEORGE GARRATTY: "Antibody against poly(ethylene glycol) adversely affects PEG‐asparaginase therapy in acute lymphoblastic leukemia patients", CANCER, AMERICAN CANCER SOCIETY , PHILADELPHIA , PA, US, vol. 110, no. 1, 21 May 2007 (2007-05-21), US , pages 103 - 111, XP071175423, ISSN: 0008-543X, DOI: 10.1002/cncr.22739
Attorney, Agent or Firm:
SHOSU Takeshi (JP)
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