Title:
ANTI-TETRANOR-PGDM MONOCLONAL ANTIBODY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/177003
Kind Code:
A1
Abstract:
The present invention provides a monoclonal antibody capable of binding to tetranor-PGDM specifically or a fragment of the monoclonal antibody.
Inventors:
MURATA TAKAHISA (JP)
NAKAMURA TATSURO (JP)
NAGATA NANAE (JP)
ARITAKE KOSUKE (JP)
MASUKO SAKURA (JP)
NAKAMURA TATSURO (JP)
NAGATA NANAE (JP)
ARITAKE KOSUKE (JP)
MASUKO SAKURA (JP)
Application Number:
PCT/JP2022/006890
Publication Date:
August 25, 2022
Filing Date:
February 21, 2022
Export Citation:
Assignee:
UNIV TOKYO (JP)
TSUZUKI EDUCATIONAL INST (JP)
TSUZUKI EDUCATIONAL INST (JP)
International Classes:
C12N15/13; A61K39/395; A61P37/08; C07K16/18; C07K16/44; C07K17/00; C12N1/15; C12N1/19; C12N5/10; C12N5/12; G01N33/50; G01N33/53
Domestic Patent References:
| WO2010104025A1 | 2010-09-16 | |||
| WO2009043015A1 | 2009-04-02 | |||
| WO2016021704A1 | 2016-02-11 | |||
| WO2016021704A1 | 2016-02-11 |
Foreign References:
| US20120021437A1 | 2012-01-26 | |||
| US20120021437A1 | 2012-01-26 |
Other References:
NAGATA NANAE, MASUKO SAKURA, INOUE RIKAKO, NAKAMURA TATSURO, ARITAKE KOSUKE, MURATA TAKAHISA: "Development of Monoclonal Antibody-Based EIA for Tetranor-PGDM which Reflects PGD2 Production in the Body", JOURNAL OF IMMUNOLOGY RESEARCH, HINDAWI PUBLISHING CORPORATION, US, vol. 2021, 26 April 2021 (2021-04-26), US , pages 1 - 6, XP055962376, ISSN: 2314-8861, DOI: 10.1155/2021/5591115
J BIOL CHEM., vol. 14, no. 33, 2009, pages 22344 - 52
MAEDA SNAKAMURA THARADA HTACHIBANA YARITAKE KSHIMOSAWA T ET AL.: "Prostaglandin D2 metabolite in urine is an index of food allergy", SCI REP, vol. 7, no. 1, 17 December 2017 (2017-12-17), pages 17687, XP055595064, DOI: 10.1038/s41598-017-17798-w
INAGAKI SMAEDA SNARITA MNAKAMURA TSHIMOSAWA TMURATA T ET AL.: "Urinary PGDM, a prostaglandin D2 metabolite, is a novel biomarker for objectively detecting allergic reactions of food allergy", J ALLERGY CLIN IMMUNOL., vol. 142, no. 5, 2018, pages 1634 - 6, XP085525212, DOI: 10.1016/j.jaci.2018.06.032
TAKESHITA EKOMAKI HTACHIMORI HMIYOSHI KYAMAMIYA ISHIMIZU-MOTOHASHI Y ET AL.: "Urinary prostaglandin metabolites as Duchenne muscular dystrophy progression markers", BRAIN DEV., vol. 40, no. 10, 15 July 2018 (2018-07-15), pages 918 - 25, XP085476013, DOI: 10.1016/j.braindev.2018.06.012
HIGASHI ET AL.: "Urinary tetranor-PGDM concentrations in aspirin-intolerant asthma and anaphylaxis", J ALLERGY CLIN IMMUNOL., vol. 129, no. 2, 22 October 2011 (2011-10-22), pages 557 - 9
SONG WLWANG MRICCIOTTI EFRIES SYU YGROSSER T ET AL.: "Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans", J BIOL CHEM., vol. 283, no. 2, 13 November 2007 (2007-11-13), pages 1179 - 88, XP055097681, DOI: 10.1074/jbc.M706839200
MAEDA SNAKAMURA THARADA HTACHIBANA YARITAKE KSHIMOSAWA T ET AL.: "Prostaglandin D2 metabolite in urine is an index of food allergy", SCI REP, 2017
INAGAKI SMAEDA SNARITA MNAKAMURA TSHIMOSAWA TMURATA T ET AL.: "Urinary PGDM, a prostaglandin D2 metabolite, is a novel biomarker for objectively detecting allergic reactions of food allergy", J ALLERGY CLIN IMMUNOL, vol. 142, no. 5, 10 July 2018 (2018-07-10), pages 1634 - 6, XP085525212, DOI: 10.1016/j.jaci.2018.06.032
HIGASHI NMITA HYAMAGUCHI HFUKUTOMI YAKIYAMA KTANIGUCHI M: "Urinary tetranor-PGDM concentrations in aspirin-intolerant asthma and anaphylaxis", J ALLERGY CLIN IMMUNOL., vol. 129, no. 2, 25 October 2011 (2011-10-25), pages 557 - 9
HARLOW ELANE D: "Antibodies: a laboratory manual", 1988, COLD SPRING HARBOR LABORATORY, pages: 726
QUEFFELECALBOISDE FLARUE JPHAELTERS JPCORBEL BTHOUVENOT D ET AL.: "Development of an immunoassay (ELISA) for the quantification of thiram in lettuce", J AGRIC FOOD CHEM., vol. 49, no. 4, 20 April 2001 (2001-04-20), pages 1675 - 80
DUDLEY RAEDWARDS PEKINS RPFINNEY DJMCKENZIE IGRAAB GM ET AL.: "Guidelines for immunoassay data processing", CLIN CHEM., vol. 31, no. 8, 1 August 1985 (1985-08-01), pages 1264 - 71
HAYASHI YMATSUDA RMAITANI TIMAI KNISHIMURA WITO K ET AL.: "Precision, limit of detection and range of quantitation in competitive ELISA", ANAL CHEM., vol. 76, no. 5, 2004, pages 1295 - 301
SCHNEIDER DGEE SKREISSIG SHARRIS AKRAMER PMARCO M ET AL.: "New frontiers in agrochemical immunoassay", AOAC INTERNATIONAL, WASHINGTON DC, vol. 1, 1995
SMITH-PALMER T: "Separation methods applicable to urinary creatine and creatinine", J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI, vol. 781, 27 November 2002 (2002-11-27), pages 93 - 106, XP004394150, DOI: 10.1016/S1570-0232(02)00617-7
GRANSTROM ESAMUELSSON B: "On the metabolism of prostaglandin F 2 in female subjects. II. Structures of six metabolites", J BIOL CHEM., vol. 246, no. 24, 25 December 1971 (1971-12-25), pages 7470 - 85
ZHANG YZHANG GCLARKE PAHUANG JTTAKAHASHI EMUIRHEAD D ET AL.: "Simultaneous and high-throughput quantitation of urinary tetranor PGDM and tetranor PGEM by online SPE-LC-MS/MS as inflammatory biomarkers", J MASS SPECTROM., vol. 46, no. 7, 28 June 2011 (2011-06-28), pages 705 - 11, XP055433984, DOI: 10.1002/jms.1941
J BIOL CHEM., vol. 14, no. 33, 2009, pages 22344 - 52
MAEDA SNAKAMURA THARADA HTACHIBANA YARITAKE KSHIMOSAWA T ET AL.: "Prostaglandin D2 metabolite in urine is an index of food allergy", SCI REP, vol. 7, no. 1, 17 December 2017 (2017-12-17), pages 17687, XP055595064, DOI: 10.1038/s41598-017-17798-w
INAGAKI SMAEDA SNARITA MNAKAMURA TSHIMOSAWA TMURATA T ET AL.: "Urinary PGDM, a prostaglandin D2 metabolite, is a novel biomarker for objectively detecting allergic reactions of food allergy", J ALLERGY CLIN IMMUNOL., vol. 142, no. 5, 2018, pages 1634 - 6, XP085525212, DOI: 10.1016/j.jaci.2018.06.032
TAKESHITA EKOMAKI HTACHIMORI HMIYOSHI KYAMAMIYA ISHIMIZU-MOTOHASHI Y ET AL.: "Urinary prostaglandin metabolites as Duchenne muscular dystrophy progression markers", BRAIN DEV., vol. 40, no. 10, 15 July 2018 (2018-07-15), pages 918 - 25, XP085476013, DOI: 10.1016/j.braindev.2018.06.012
HIGASHI ET AL.: "Urinary tetranor-PGDM concentrations in aspirin-intolerant asthma and anaphylaxis", J ALLERGY CLIN IMMUNOL., vol. 129, no. 2, 22 October 2011 (2011-10-22), pages 557 - 9
SONG WLWANG MRICCIOTTI EFRIES SYU YGROSSER T ET AL.: "Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans", J BIOL CHEM., vol. 283, no. 2, 13 November 2007 (2007-11-13), pages 1179 - 88, XP055097681, DOI: 10.1074/jbc.M706839200
MAEDA SNAKAMURA THARADA HTACHIBANA YARITAKE KSHIMOSAWA T ET AL.: "Prostaglandin D2 metabolite in urine is an index of food allergy", SCI REP, 2017
INAGAKI SMAEDA SNARITA MNAKAMURA TSHIMOSAWA TMURATA T ET AL.: "Urinary PGDM, a prostaglandin D2 metabolite, is a novel biomarker for objectively detecting allergic reactions of food allergy", J ALLERGY CLIN IMMUNOL, vol. 142, no. 5, 10 July 2018 (2018-07-10), pages 1634 - 6, XP085525212, DOI: 10.1016/j.jaci.2018.06.032
HIGASHI NMITA HYAMAGUCHI HFUKUTOMI YAKIYAMA KTANIGUCHI M: "Urinary tetranor-PGDM concentrations in aspirin-intolerant asthma and anaphylaxis", J ALLERGY CLIN IMMUNOL., vol. 129, no. 2, 25 October 2011 (2011-10-25), pages 557 - 9
HARLOW ELANE D: "Antibodies: a laboratory manual", 1988, COLD SPRING HARBOR LABORATORY, pages: 726
QUEFFELECALBOISDE FLARUE JPHAELTERS JPCORBEL BTHOUVENOT D ET AL.: "Development of an immunoassay (ELISA) for the quantification of thiram in lettuce", J AGRIC FOOD CHEM., vol. 49, no. 4, 20 April 2001 (2001-04-20), pages 1675 - 80
DUDLEY RAEDWARDS PEKINS RPFINNEY DJMCKENZIE IGRAAB GM ET AL.: "Guidelines for immunoassay data processing", CLIN CHEM., vol. 31, no. 8, 1 August 1985 (1985-08-01), pages 1264 - 71
HAYASHI YMATSUDA RMAITANI TIMAI KNISHIMURA WITO K ET AL.: "Precision, limit of detection and range of quantitation in competitive ELISA", ANAL CHEM., vol. 76, no. 5, 2004, pages 1295 - 301
SCHNEIDER DGEE SKREISSIG SHARRIS AKRAMER PMARCO M ET AL.: "New frontiers in agrochemical immunoassay", AOAC INTERNATIONAL, WASHINGTON DC, vol. 1, 1995
SMITH-PALMER T: "Separation methods applicable to urinary creatine and creatinine", J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI, vol. 781, 27 November 2002 (2002-11-27), pages 93 - 106, XP004394150, DOI: 10.1016/S1570-0232(02)00617-7
GRANSTROM ESAMUELSSON B: "On the metabolism of prostaglandin F 2 in female subjects. II. Structures of six metabolites", J BIOL CHEM., vol. 246, no. 24, 25 December 1971 (1971-12-25), pages 7470 - 85
ZHANG YZHANG GCLARKE PAHUANG JTTAKAHASHI EMUIRHEAD D ET AL.: "Simultaneous and high-throughput quantitation of urinary tetranor PGDM and tetranor PGEM by online SPE-LC-MS/MS as inflammatory biomarkers", J MASS SPECTROM., vol. 46, no. 7, 28 June 2011 (2011-06-28), pages 705 - 11, XP055433984, DOI: 10.1002/jms.1941
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
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