Title:
BORON NEUTRON CAPTURE THERAPY (BNCT) PROBE
Document Type and Number:
WIPO Patent Application WO/2022/177002
Kind Code:
A1
Abstract:
[Problem] To provide a novel compound promising as a probe for a boron neutron capture therapy (BNCT). [Solution] A compound represented by general formula (I) below or a salt thereof.
Inventors:
URANO YASUTERU (JP)
KAMIYA MAKO (JP)
TSUNETOMI JUNYA (JP)
KAMIYA MAKO (JP)
TSUNETOMI JUNYA (JP)
Application Number:
PCT/JP2022/006876
Publication Date:
August 25, 2022
Filing Date:
February 21, 2022
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
C07F5/05; A61K51/04; A61P35/00
Domestic Patent References:
| WO2019172210A1 | 2019-09-12 |
Other References:
YU-LING HSU, MANJULA NANDAKUMAR, HSIN-YI LAI, TZYY-CHAO CHOU, CHI-YUAN CHU, CHUN-HUNG LIN, LEE-CHIANG LO: "-Fucosidases in Cells", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 80, no. 16, 21 August 2015 (2015-08-21), pages 8458 - 8463, XP055537688, ISSN: 0022-3263, DOI: 10.1021/acs.joc.5b01204
KALOT GHADIR, GODARD AMÉLIE, BUSSER BENOÎT, PLIQUETT JACQUES, BROEKGAARDEN MANS, MOTTO-ROS VINCENT, WEGNER KARL DAVID, RESCH-GENGE: "Aza-BODIPY: A New Vector for Enhanced Theranostic Boron Neutron Capture Therapy Applications", CELLS, vol. 9, no. 9, 1 September 2020 (2020-09-01), pages 1953 - 14, XP055959621, ISSN: 2073-4409, DOI: 10.3390/cells9091953
HIROYUKI NAKAMURA: "Historical Development and Current Status of Boron Delivery Agents for Boron Neutron Capture Therapy", RAIOISOTOPES, TOKYO, JP, vol. 64, no. 1, 15 January 2015 (2015-01-15), JP , pages 47 - 58, XP055605833, ISSN: 0033-8303, DOI: 10.3769/radioisotopes.64.47
TSUNETOMI JUNYA, MAKO KAMIYA, YASUTERU URANO: "Development of a novel small-molecule boron drug for BNCT using biomarker enzyme activity of cancer cells", THE 141ST ANNUAL MEETING OF THE PHARMACEUTICAL SOCIETY OF JAPAN (HIROSHIMA). MARCH 26TH-29TH, 2021, PHARMACEUTICAL SOCIETY OF JAPAN, JP, 1 March 2021 (2021-03-01) - 29 March 2021 (2021-03-29), JP, pages 28V06 - am05S, XP055959626
KALOT GHADIR, GODARD AMÉLIE, BUSSER BENOÎT, PLIQUETT JACQUES, BROEKGAARDEN MANS, MOTTO-ROS VINCENT, WEGNER KARL DAVID, RESCH-GENGE: "Aza-BODIPY: A New Vector for Enhanced Theranostic Boron Neutron Capture Therapy Applications", CELLS, vol. 9, no. 9, 1 September 2020 (2020-09-01), pages 1953 - 14, XP055959621, ISSN: 2073-4409, DOI: 10.3390/cells9091953
HIROYUKI NAKAMURA: "Historical Development and Current Status of Boron Delivery Agents for Boron Neutron Capture Therapy", RAIOISOTOPES, TOKYO, JP, vol. 64, no. 1, 15 January 2015 (2015-01-15), JP , pages 47 - 58, XP055605833, ISSN: 0033-8303, DOI: 10.3769/radioisotopes.64.47
TSUNETOMI JUNYA, MAKO KAMIYA, YASUTERU URANO: "Development of a novel small-molecule boron drug for BNCT using biomarker enzyme activity of cancer cells", THE 141ST ANNUAL MEETING OF THE PHARMACEUTICAL SOCIETY OF JAPAN (HIROSHIMA). MARCH 26TH-29TH, 2021, PHARMACEUTICAL SOCIETY OF JAPAN, JP, 1 March 2021 (2021-03-01) - 29 March 2021 (2021-03-29), JP, pages 28V06 - am05S, XP055959626
Attorney, Agent or Firm:
ONO Makoto et al. (JP)
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