ANTI-TRICHOPHYTIC ADHESIVE PATCH

WIPO Patent Application WO/2014/021284

A1

The present invention provides an adhesive patch for nails and/or skin, which has anti-trichophyton activity and high nail permeability. An adhesive patch for nails and/or skin for prophylaxis or treatment of trichophytosis, which contains a compound represented by general formula (I) or a salt thereof in an adhesive layer. (In the formula, R1 represents a hydrogen atom, a C1-6 alkyl group or a trifluoromethyl group; R2 represents a hydrogen atom, a C1-6 alkyl group, a halogen atom, a -COO(C1-6 alkyl) group or a (CH2)1-3COOR group (wherein R represents a hydrogen atom or a C1-6 alkyl group); R3 represents a hydrogen atom, a C1-6 alkyl group, an amino group, a trifluoromethyl group or an OR group (wherein R represents a hydrogen atom or a C1-6 alkyl group); R4 represents a hydroxyl group; R5 represents a hydrogen atom, a C1-6 alkyl group, a hydroxyl group or a halogen atom; R6 represents a hydrogen atom, a C1-6 alkyl group, a trifluoromethyl group, a halogen atom, an amino group, an -NRaRb group, a nitro group, a hydroxy C1-6 alkyl group, a -CONRaRb group, a -COO(C1-6 alkyl) group, a -COOH group, a -(CH2)1-3COOR group or an ORa group (wherein R represents a hydrogen atom or a C1-6 alkyl group; and Ra and Rb may be the same or different, and each represents a hydrogen atom, a C1-6 alkyl group or a C1-6 acyl group); R7 represents a hydrogen atom, a C1-6 alkyl group, an -OR group (wherein R represents a hydrogen atom or a C1-6 alkyl group) or a halogen atom; and R8 represents a hydrogen atom, a C1-6 alkyl group, a hydroxyl group, an amino group or a nitro group.)

JPH02131485	3-SUBSTITUTED TETRAHYDROTHIOPYRANO(2,3-B)INDOLE DERIVATIVE AND INTERMEDIATE THEREFOR
WO/2011/054732	PROCESS FOR PREPARING 1,3-DISUBSTITUTED PYRAZOLE COMPOUNDS
WO/1986/002645	NEW AMINO COMPOUNDS, PREPARATION PROCESS THEREOF, UTILIZATION THEREOF AND DRUGS CONTAINING THEM

KAWAHARA KOJI (JP)
KAN NORIKO (JP)
NOZAWA SHIHOKO (JP)
MATSUO KYOHEI (JP)

PCT/JP2013/070527

February 06, 2014

July 30, 2013

Click for automatic bibliography generation  

MEIJI SEIKA PHARMA CO LTD (JP)
NICHIBAN KK (JP)

A61K31/415; A61K9/70; A61K47/32; A61P17/00; A61P31/10

WO2012102404A1	2012-08-02
WO2004033432A1	2004-04-22
WO2003005999A2	2003-01-23
WO2007083320A2	2007-07-26

JPS6368569A	1988-03-28
JP4284169B2	2009-06-24
ES2015648A6	1990-09-01
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US20070105866A1	2007-05-10
JPH0853401A	1996-02-27
JPH08188545A	1996-07-23
JPH1160528A	1999-03-02
JP2006213650A	2006-08-17

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TSUKUNI & ASSOCIATES et al. (JP)
Patent business corporation Tsukuni (JP)

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