Title:
ANTI-TUMOR PACLITAXEL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2024/002127
Kind Code:
A1
Abstract:
Provided is an anti-tumor paclitaxel compound. Specifically, provided are a hydrate and a crystal form of 2'-acetyl docetaxel. The hydrate or the preferred crystal form A of 2'-acetyl docetaxel is superior to other crystal forms or amorphous forms in terms of solid stability, hygroscopicity, and mechanical stability, and has better druggability and clinical application values.
Inventors:
QU FANZHI (CN)
ZHANG XIAOJUN (CN)
BAI JIE (CN)
LIU FANGRU (CN)
SHAO YONG (CN)
ZHAO YUANYUAN (CN)
CHEN DONGJIAN (CN)
WANG XUEFEI (CN)
DONG YUE (CN)
LIU HAIRUI (CN)
ZHANG XIAOJUN (CN)
BAI JIE (CN)
LIU FANGRU (CN)
SHAO YONG (CN)
ZHAO YUANYUAN (CN)
CHEN DONGJIAN (CN)
WANG XUEFEI (CN)
DONG YUE (CN)
LIU HAIRUI (CN)
Application Number:
PCT/CN2023/103044
Publication Date:
January 04, 2024
Filing Date:
June 28, 2023
Export Citation:
Assignee:
CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD (CN)
International Classes:
C07D305/14; A61K31/337; A61P35/00
Domestic Patent References:
| WO2010123186A1 | 2010-10-28 |
Foreign References:
| CN101343262A | 2009-01-14 | |||
| CN101735179A | 2010-06-16 | |||
| KR20100099360A | 2010-09-13 | |||
| CN102050804A | 2011-05-11 |
Other References:
SHEN, XIN ET AL.: "An Efficient Semi-Synthetic Method to Construct Docetaxel via Sterically Crowded Linear Side Chain Esterification", CHIN. J. CHEM., vol. 31, 8 January 2013 (2013-01-08), XP055477642, DOI: 10.1002/cjoc.201201142
DUBOIS J, ET AL.: "CONFORMATION OF TAXOTERE AND ANALOGUES DETERMINED BY NMR SPECTROSCOPY AND MOLECULAR MODELING STUDIES", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 49, no. 30, 22 July 1993 (1993-07-22), AMSTERDAM, NL , pages 6533 - 6544, XP001181765, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)81822-6
XU MEI-QI, ZHONG TING, YAO XIN, LI ZHUO-YUE, LI HUI, WANG JING-RU, FENG ZHEN-HAN, ZHANG XUAN: "Effect of XlogP and hansen solubility parameters on the prediction of small molecule modified docetaxel, doxorubicin and irinotecan conjugates forming stable nanoparticles", DRUG DELIVERY, ACADEMIC PRESS, ORLANDO, FL., US, vol. 28, no. 1, 1 January 2021 (2021-01-01), US , pages 1603 - 1615, XP093122012, ISSN: 1071-7544, DOI: 10.1080/10717544.2021.1958107
DUBOIS J, ET AL.: "CONFORMATION OF TAXOTERE AND ANALOGUES DETERMINED BY NMR SPECTROSCOPY AND MOLECULAR MODELING STUDIES", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 49, no. 30, 22 July 1993 (1993-07-22), AMSTERDAM, NL , pages 6533 - 6544, XP001181765, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)81822-6
XU MEI-QI, ZHONG TING, YAO XIN, LI ZHUO-YUE, LI HUI, WANG JING-RU, FENG ZHEN-HAN, ZHANG XUAN: "Effect of XlogP and hansen solubility parameters on the prediction of small molecule modified docetaxel, doxorubicin and irinotecan conjugates forming stable nanoparticles", DRUG DELIVERY, ACADEMIC PRESS, ORLANDO, FL., US, vol. 28, no. 1, 1 January 2021 (2021-01-01), US , pages 1603 - 1615, XP093122012, ISSN: 1071-7544, DOI: 10.1080/10717544.2021.1958107
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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