ANTI-WARS1 ANTIBODY AND USE THEREOF

Title:

ANTI-WARS1 ANTIBODY AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/211229

Kind Code:

A1

Abstract:

The present invention relates to an anti-WARS1 antibody, and a pharmaceutical composition comprising same as an active ingredient. The anti-WARS1 antibody according to the present invention specifically binds to WARS1 and can inhibit the secretion of TNF-α induced by WARS1. In addition, the anti-WARS1 antibody according to the present invention can be effectively used to prevent or treat inflammatory diseases including sepsis, chronic obstructive pulmonary disease, inflammatory bowel disease, rheumatoid arthritis, atopic dermatitis, macrophage activating syndrome, and the like.

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Inventors:

JIN MIRIM (KR)
KANG BYOUNG CHEOL (KR)
CHOI YUN HUI (KR)
JANG JINAH (KR)
YOON HEEKYEONG (KR)
JO LEE SEUL (KR)
SEO RIRA (KR)
NGUYEN THUY THUY TRAM (KR)

Application Number:

PCT/KR2023/005828

Publication Date:

November 02, 2023

Filing Date:

April 27, 2023

Export Citation:

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Assignee:

MIRIMGENE CO LTD (KR)

International Classes:

C07K16/40; A61K39/00; A61P29/00

Foreign References:

KR20210010236A	2021-01-27
KR101899591B1	2018-09-17
KR101729547B1	2017-04-25

Other References:

JIN MIRIM, JIN MIRIM: "Unique roles of tryptophanyl-tRNA synthetase in immune control and its therapeutic implications", EXPERIMENTAL AND MOLECULAR MEDICINE, SEOUL, KR, vol. 51, no. 1, 1 January 2019 (2019-01-01), KR , pages 1 - 10, XP055924828, ISSN: 1226-3613, DOI: 10.1038/s12276-018-0196-9
YU YA CHUN; HAN JUNG MIN; KIM SUNGHOON: "Aminoacyl-tRNA synthetases and amino acid signaling", BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, vol. 1868, no. 1, 20 October 2020 (2020-10-20), NL , XP086349114, ISSN: 0167-4889, DOI: 10.1016/j.bbamcr.2020.118889

Attorney, Agent or Firm:

RYU, Jong Woo et al. (KR)

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