Title:
ANTIBACTERIAL, ANTIOXIDANT HYDROGEL DRESSING FOR TREATING DIABETIC WOUNDS AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/231051
Kind Code:
A1
Abstract:
The present invention relates to an antibacterial, antioxidant hydrogel dressing for treating diabetic wounds and a preparation method therefor. The dressing is obtained by cross-linking epoxy groups in a gel-forming framework polymer containing glycidyl methacrylate with amino groups in an electrostatic complex of hyperbranched polylysines and a manganese dioxide nanosheet by means of a ring-opening reaction. A multifunctional injectable hydrogel with antibacterial activity, active oxygen removal, oxygen supply and drug release can be prepared by combining a drug promoting nitric oxide synthesis. By means of electrostatic compounding of hyperbranched polylysines and the manganese dioxide nanosheet, the problem that manganese dioxide has poor stability in physiological environments is solved. The in-vitro characterization of the hydrogel confirms its good antibacterial performance and excellent performance in removing active oxygen or free radicals such as diphenyl picrylhydrazyl radicals, hydrogen peroxide, hydroxyl radicals and superoxide anions. The hydrogel dressing can be used for treating wounds in patients with type II diabetes. The hydrogel dressing can help diabetic infection wounds transition steadily from an inflammatory phase to a proliferative phase, accelerating the organized repair of wounds.
Inventors:
GAO CHANGYOU (CN)
LIU XIAOQING (CN)
TU CHENXI (CN)
LIU XIAOQING (CN)
TU CHENXI (CN)
Application Number:
PCT/CN2022/097165
Publication Date:
December 07, 2023
Filing Date:
June 06, 2022
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
SHAOXING RESEARCH INSTITUTE OF ZHEJIANG UNIV (CN)
SHAOXING RESEARCH INSTITUTE OF ZHEJIANG UNIV (CN)
International Classes:
A61L26/00; C08J3/075; C08K3/22; C08K7/00; C08L51/08; C08L77/04
Foreign References:
| CN113842493A | 2021-12-28 | |||
| CN114230817A | 2022-03-25 | |||
| CN113577377A | 2021-11-02 | |||
| US4781921A | 1988-11-01 |
Other References:
TU CHENXI, LU HUIDAN, ZHOU TONG, ZHANG WANYING, DENG LIWEN, CAO WANGBEI, YANG ZHIJIAN, WANG ZHAOLONG, WU XINYU, DING JIE, XU FENG,: "Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 286, 1 July 2022 (2022-07-01), AMSTERDAM, NL , pages 121597, XP093116978, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2022.121597
Attorney, Agent or Firm:
HANGZHOU QIUSHI PATENT OFFICE CO., LTD. (CN)
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