Title:
TOUGH ANTIBACTERIAL HYDROGEL DRESSING AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/231050
Kind Code:
A1
Abstract:
The present invention relates to a tough antibacterial hydrogel dressing and a preparation method therefor. According to the hydrogel dressing, gel formation is based on a hydrogen bond effect of a gel-forming framework such as polyvinyl alcohol, gelatin and collagen, hyperbranched polylysine is mixed before the gel formation, and after the gel formation, mechanical properties are enhanced by means of soaking in an ionic solution. Physical gel formation by the hydrogen bond effect can avoid the problem of toxicity caused by residual crosslinking agents in a chemical crosslinking method. Furthermore, the defect of poor mechanical properties of the hydrogel obtained by a physical crosslinking method is overcome by means of Hofmeister effect salting out. The prepared hydrogel dressing has good tensile and compression properties and an antibacterial property. The provided hydrogel dressing is suitable for various skin wounds, simple and convenient in the preparation method, high in repeatability, low in cost, and expected to be widely applied in the field of antibacterial skin dressings.
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Inventors:
GAO CHANGYOU (CN)
LIU XIAOQING (CN)
WANG QIUYI (CN)
LIU XIAOQING (CN)
WANG QIUYI (CN)
Application Number:
PCT/CN2022/097164
Publication Date:
December 07, 2023
Filing Date:
June 06, 2022
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
SHAOXING RESEARCH INSTITUTE OF ZHEJIANG UNIV (CN)
SHAOXING RESEARCH INSTITUTE OF ZHEJIANG UNIV (CN)
International Classes:
A61L26/00; C08J3/075; C08L77/04; C08L89/00
Foreign References:
| CN110507845A | 2019-11-29 | |||
| CN113577377A | 2021-11-02 | |||
| CN112190763A | 2021-01-08 | |||
| KR20190114662A | 2019-10-10 | |||
| CN113621135A | 2021-11-09 | |||
| CN101982202A | 2011-03-02 |
Attorney, Agent or Firm:
HANGZHOU QIUSHI PATENT OFFICE CO., LTD. (CN)
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