ANTIBODIES AND RELATED MOLECULES THAT BIND TO PSCA PROTEINS

Title:

ANTIBODIES AND RELATED MOLECULES THAT BIND TO PSCA PROTEINS

Document Type and Number:

WIPO Patent Application WO2005118864

Kind Code:

A3

Abstract:

Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.

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Inventors:

GUDAS JEAN (US)
JAKOBOVITS AYA (US)
JIA XIAO-CHI (US)
MORRISON ROBERT KENDALL (US)
MORRISON KAREN JANE MEYRICK (US)
SHAO HUI (US)
CHALLITA-EID PIA M (US)
RAITANO ARTHUR B (US)

Application Number:

PCT/US2005/017412

Publication Date:

February 09, 2006

Filing Date:

May 17, 2005

Export Citation:

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Assignee:

AGENSYS INC (US)
GUDAS JEAN (US)
JAKOBOVITS AYA (US)
JIA XIAO-CHI (US)
MORRISON ROBERT KENDALL (US)
MORRISON KAREN JANE MEYRICK (US)
SHAO HUI (US)
CHALLITA-EID PIA M (US)
RAITANO ARTHUR B (US)

International Classes:

C07H21/04; C07K14/705; C07K16/30; C12N15/09; C12P21/06; C12Q1/68; A61K39/00; (IPC1-7): C12Q1/00; G01N33/53; A01N61/00

Foreign References:

US6258939B1

2001-07-10

Other References:

GU ET AL: "Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer.", ONCOGENE., vol. 19, March 2000 (2000-03-01), pages 1288 - 1296, XP000891893
SAFFRAN ET AL: "Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts.", PROC NATL ACAD SCI., vol. 98, no. 5, February 2001 (2001-02-01), pages 2658 - 2663, XP000999115

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