Title:
DIAGNOSIS AND TREATMENT OF DRUG RESISTANT LEUKEMIA
Document Type and Number:
WIPO Patent Application WO2005118865
Kind Code:
A3
Abstract:
The present invention encompasses methods and compositions useful in the diagnosis and treatment of drug resistant leukemia. The invention provides a number of genes that are differentially expressed between drug resistant and drug sensitive acute lymphoblastic leukemia (ALL). These genes act as biomarkers for drug resistant leukemia, and further serve as molecular targets for drugs useful in treating drug resistant leukemia. Accordingly, the invention provides methods of diagnosing drug resistant leukemia and methods of selecting a therapy for subjects affected by drug-resistant leukemia. The invention also provides methods for screening for compounds for treating drug-resistant leukemia, and improved methods for treating drug-resistant leukemia. Compositions of the invention include arrays, computer readable media, and kits for use in the methods of the invention.
Inventors:
EVANS WILLIAM E (US)
PIETERS ROB (NL)
CHEOK MEYLING H (US)
DEN BOER MONIQUE L (NL)
YANG WENJIAN (US)
PIETERS ROB (NL)
CHEOK MEYLING H (US)
DEN BOER MONIQUE L (NL)
YANG WENJIAN (US)
Application Number:
PCT/US2005/017424
Publication Date:
June 22, 2006
Filing Date:
May 18, 2005
Export Citation:
Assignee:
ST JUDE CHILDRENS RES HOSPITAL (US)
EVANS WILLIAM E (US)
PIETERS ROB (NL)
CHEOK MEYLING H (US)
DEN BOER MONIQUE L (NL)
YANG WENJIAN (US)
EVANS WILLIAM E (US)
PIETERS ROB (NL)
CHEOK MEYLING H (US)
DEN BOER MONIQUE L (NL)
YANG WENJIAN (US)
International Classes:
C12Q1/68
Domestic Patent References:
| WO2001055455A2 | 2001-08-02 | |||
| WO2003087315A2 | 2003-10-23 | |||
| WO2003087404A1 | 2003-10-23 |
Other References:
DEN BOER M L ET AL: "Patient stratification based on prednisolone-vincristine-asparaginase resistance profiles in children with acute lymphoblastic leukemia.", JOURNAL OF CLINICAL ONCOLOGY, vol. 21, no. 17, 1 September 2003 (2003-09-01), pages 3262 - 3268, XP002363590, ISSN: 0732-183X
KASPERS G J ET AL: "In vitro cellular drug resistance and prognosis in newly diagnosed childhood acute lymphoblastic leukemia.", BLOOD, vol. 90, no. 7, 1 October 1997 (1997-10-01), pages 2723 - 2729, XP002363591, ISSN: 0006-4971
CHIARETTI SABINA ET AL: "Gene expression profile of adult T-cell acute lymphocytic leukemia identifies distinct subsets of patients with different response to therapy and survival.", BLOOD. 1 APR 2004, vol. 103, no. 7, 1 April 2004 (2004-04-01), pages 2771 - 2778, XP002363618, ISSN: 0006-4971
YEOH E-J ET AL: "Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling", CANCER CELL, XX, US, vol. 1, no. 2, March 2002 (2002-03-01), pages 133 - 143, XP002253604, ISSN: 1535-6108
BUBNOFF VON N ET AL: "Gene expression profiles of leukemic cells isolated from patients with chronic myeloid leukemia (CML) and Philadelphia-positive acute lymphoblastic leukemia (PH+ ALL) receiving the Abl-kinase inhibitor STI571", BLOOD, vol. 98, no. 11 Part 1, 16 November 2001 (2001-11-16), pages 567a, XP002253603, ISSN: 0006-4971
MATSUZAKI A ET AL: "Treatment of high-risk acute lymphoblastic leukemia in children using the AL851 and ALHR88 protocols: a report from the Kyushu-Yamaguchi Children's Cancer Study Group in Japan.", MEDICAL AND PEDIATRIC ONCOLOGY. JAN 1996, vol. 26, no. 1, January 1996 (1996-01-01), pages 10 - 19, XP008058890, ISSN: 0098-1532
HOLLEMAN AMY ET AL: "Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment.", THE NEW ENGLAND JOURNAL OF MEDICINE. 5 AUG 2004, vol. 351, no. 6, 5 August 2004 (2004-08-05), pages 533 - 542, XP008058562, ISSN: 1533-4406
CARROLL WILLIAM L ET AL: "Building better therapy for children with acute lymphoblastic leukemia", CANCER CELL, vol. 7, no. 4, April 2005 (2005-04-01), pages 289 - 291, XP002363592, ISSN: 1535-6108
LUGTHART SANNE ET AL: "Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia.", CANCER CELL. APR 2005, vol. 7, no. 4, April 2005 (2005-04-01), pages 375 - 386, XP002363593, ISSN: 1535-6108
KASPERS G J ET AL: "In vitro cellular drug resistance and prognosis in newly diagnosed childhood acute lymphoblastic leukemia.", BLOOD, vol. 90, no. 7, 1 October 1997 (1997-10-01), pages 2723 - 2729, XP002363591, ISSN: 0006-4971
CHIARETTI SABINA ET AL: "Gene expression profile of adult T-cell acute lymphocytic leukemia identifies distinct subsets of patients with different response to therapy and survival.", BLOOD. 1 APR 2004, vol. 103, no. 7, 1 April 2004 (2004-04-01), pages 2771 - 2778, XP002363618, ISSN: 0006-4971
YEOH E-J ET AL: "Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling", CANCER CELL, XX, US, vol. 1, no. 2, March 2002 (2002-03-01), pages 133 - 143, XP002253604, ISSN: 1535-6108
BUBNOFF VON N ET AL: "Gene expression profiles of leukemic cells isolated from patients with chronic myeloid leukemia (CML) and Philadelphia-positive acute lymphoblastic leukemia (PH+ ALL) receiving the Abl-kinase inhibitor STI571", BLOOD, vol. 98, no. 11 Part 1, 16 November 2001 (2001-11-16), pages 567a, XP002253603, ISSN: 0006-4971
MATSUZAKI A ET AL: "Treatment of high-risk acute lymphoblastic leukemia in children using the AL851 and ALHR88 protocols: a report from the Kyushu-Yamaguchi Children's Cancer Study Group in Japan.", MEDICAL AND PEDIATRIC ONCOLOGY. JAN 1996, vol. 26, no. 1, January 1996 (1996-01-01), pages 10 - 19, XP008058890, ISSN: 0098-1532
HOLLEMAN AMY ET AL: "Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment.", THE NEW ENGLAND JOURNAL OF MEDICINE. 5 AUG 2004, vol. 351, no. 6, 5 August 2004 (2004-08-05), pages 533 - 542, XP008058562, ISSN: 1533-4406
CARROLL WILLIAM L ET AL: "Building better therapy for children with acute lymphoblastic leukemia", CANCER CELL, vol. 7, no. 4, April 2005 (2005-04-01), pages 289 - 291, XP002363592, ISSN: 1535-6108
LUGTHART SANNE ET AL: "Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia.", CANCER CELL. APR 2005, vol. 7, no. 4, April 2005 (2005-04-01), pages 375 - 386, XP002363593, ISSN: 1535-6108
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