Title:
ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF THAT SPECIFICALLY BINDS TO IL-33
Document Type and Number:
WIPO Patent Application WO/2022/039455
Kind Code:
A1
Abstract:
The present invention relates to an antibody that specifically binds to IL-33, or a fragment thereof having immunological activity. A novel monoclonal antibody that binds to a specific epitope of IL-33, or a fragment thereof having immunological activity, of the present invention, may have high antigen specificity and bind to IL-33 with high affinity to interfere with binding of IL-33 and ST2, thereby acting as a neutralizing antibody which inhibits IL-33-induced MAPK and NF-κB signaling, and which can be usefully applied to the prevention or treatment of various diseases related to the release of IL-33, in particular, inflammatory diseases.
Inventors:
LEE SANGHO (KR)
PARK SOO-BIN (KR)
CHOI CHEOL-YONG (KR)
KIM SUN-JICK (KR)
LEHANTRUC CHI (KR)
HWANG DA-HYUN (KR)
CHO SANG-WOO (KR)
PARK SOO-BIN (KR)
CHOI CHEOL-YONG (KR)
KIM SUN-JICK (KR)
LEHANTRUC CHI (KR)
HWANG DA-HYUN (KR)
CHO SANG-WOO (KR)
Application Number:
PCT/KR2021/010812
Publication Date:
February 24, 2022
Filing Date:
August 13, 2021
Export Citation:
Assignee:
RESEARCH & BUSINESS FOUND SUNGKYUNKWAN UNIV (KR)
International Classes:
C07K16/24; A61K39/00; A61P29/00; G01N33/68
Domestic Patent References:
| WO2019183639A1 | 2019-09-26 |
Foreign References:
| KR20150126598A | 2015-11-12 | |||
| KR20160101940A | 2016-08-26 | |||
| KR20180128028A | 2018-11-30 | |||
| KR20160132006A | 2016-11-16 |
Other References:
PARK SOO BIN, KIM SUN-JICK, CHO SANG WOO, CHOI CHEOL YONG, LEE SANGHO: "Blocking of the IL-33/ST2 Signaling Axis by a Single-Chain Antibody Variable Fragment (scFv) Specific to IL-33 with a Defined Epitope", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 18, 22 September 2020 (2020-09-22), XP055902043, DOI: 10.3390/ijms21186953
Attorney, Agent or Firm:
KONG, Byung-Wook (KR)
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