Title:
ANTIBODY BENEFICIAL FOR TREATMENT OF SOLID TUMORS, ANTIBODY-DRUG CONJUGATE, AND CANCER DRUG INCLUDING SAME
Document Type and Number:
WIPO Patent Application WO/2019/087994
Kind Code:
A1
Abstract:
The present invention provides an antibody beneficial for the treatment of solid tumors, an antibody-drug conjugate, and a cancer drug including the antibody-drug conjugate. The present invention provides, for example: an antibody that binds to tissue factor, wherein the dissociation constant kd is at least 5 × 10-4 (1/s) and the binding constant Ka is at least 1 × 104 (1/Ms); or an antigen-binding fragment thereof.
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Inventors:
MATSUMURA YASUHIRO (JP)
YASUNAGA MASAHIRO (JP)
SAIJO SHINJI (JP)
TSUMURA RYO (JP)
YASUNAGA MASAHIRO (JP)
SAIJO SHINJI (JP)
TSUMURA RYO (JP)
Application Number:
PCT/JP2018/040017
Publication Date:
May 09, 2019
Filing Date:
October 29, 2018
Export Citation:
Assignee:
NAT CANCER CENTER JAPAN (JP)
RIN INST INC (JP)
RIN INST INC (JP)
International Classes:
C07K16/36; A61K39/395; A61K47/68; A61P35/00; C12N15/13
Domestic Patent References:
| WO1999051743A1 | 1999-10-14 | |||
| WO2015115656A1 | 2015-08-06 |
Foreign References:
| JP2012511314A | 2012-05-24 | |||
| JP2007525944A | 2007-09-13 | |||
| JP2003527861A | 2003-09-24 | |||
| JP2014509856A | 2014-04-24 | |||
| JP2013534406A | 2013-09-05 |
Other References:
KOGA YMANABE SAIHARA YSATO RTSUMURA RIWAFUJI HFURUYA FFUCHIGAMI HFUJIWARA YHISADA Y: "Antitumor effect of anti-tissue factor antibody-MMAE conjugate in human pancreatic tumor xenografts", INT. J. CANCER, vol. 137, 2015, pages 1457 - 1466
KARLSSON, R.KATSAMBA, P. S.NORDIN, H.POL, E.MYSZKA, D. G.: "Analyzing a kinetic titration series using affinity biosensors", ANAL. BIOCHEM., vol. 349, no. 1, 2006, pages 136 - 47, XP024941980, DOI: 10.1016/j.ab.2005.09.034
See also references of EP 3705495A4
KARLSSON, R.KATSAMBA, P. S.NORDIN, H.POL, E.MYSZKA, D. G.: "Analyzing a kinetic titration series using affinity biosensors", ANAL. BIOCHEM., vol. 349, no. 1, 2006, pages 136 - 47, XP024941980, DOI: 10.1016/j.ab.2005.09.034
See also references of EP 3705495A4
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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