Title:
ANTIBODY-BINDING PROTEIN HAVING REDUCED ANTIBODY BINDING CAPACITY IN ACIDIC pH REGION
Document Type and Number:
WIPO Patent Application WO/2017/014260
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an antibody-binding protein having a reduced antibody-binding capacity in an acidic pH region. Provided is a protein containing an amino acid sequence obtained by substituting a hydrophobic amino acid residue, an acidic amino acid residue, or a polar uncharged amino acid residue with a basic amino acid residue in an amino acid sequence derived from the E, D, A, B, or C domain of a protein A enumerated by SEQ ID NO: 1-5, said protein being characterized in that compared with the pre-substituted protein, the substituted protein has a reduced antibody-binding capacity in an acidic pH region.
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Inventors:
NISHIHACHIJYO MASAKATSU (JP)
NAKANO YOSHIYUKI (JP)
KONOIKE FUMINORI (JP)
TAKANO MASAYUKI (JP)
YOSHIDA SHINICHI (JP)
MINAKUCHI KAZUNOBU (JP)
NAKANO YOSHIYUKI (JP)
KONOIKE FUMINORI (JP)
TAKANO MASAYUKI (JP)
YOSHIDA SHINICHI (JP)
MINAKUCHI KAZUNOBU (JP)
Application Number:
PCT/JP2016/071367
Publication Date:
January 26, 2017
Filing Date:
July 21, 2016
Export Citation:
Assignee:
KANEKA CORP (JP)
International Classes:
C12N15/09; B01D15/08; B01J20/22; B01J20/30; B01J20/34; C07K1/22; C07K14/31; C07K17/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02
Domestic Patent References:
| WO2012165544A1 | 2012-12-06 |
Foreign References:
| JP2010081866A | 2010-04-15 |
Attorney, Agent or Firm:
YASUTOMI & ASSOCIATES (JP)
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