Title:
ANTIBODY SPECIFICALLY BINDING TO ANGIOPOIETIN-2, OR FRAGMENT THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/225182
Kind Code:
A1
Abstract:
The present invention relates to an anti-angiopoietin-2 (Ang2) antibody or an antigen-binding fragment thereof that specifically binds to Ang2 and induces Tie2 activation, comprising: (a) a heavy-chain complementarity-determining region (CDR) including CDRH1 of the amino acid sequence of SEQ ID NO: 2, SEQ ID NO: 10, SEQ ID NO: 18, or SEQ ID NO: 26, CDRH2 of the amino acid sequence of SEQ ID NO: 3, SEQ ID NO: 11, SEQ ID NO: 19, or SEQ ID NO: 27, and CDRH3 of the amino acid sequence of SEQ ID NO: 4, SEQ ID NO: 12, SEQ ID NO: 20, or SEQ ID NO: 28; and (b) a light-chain CDR including CDRL1 of the amino acid sequence of SEQ ID NO: 5, SEQ ID NO: 13, SEQ ID NO: 21, or SEQ ID NO: 29, CDRL2 of the amino acid sequence of SEQ ID NO: 6, SEQ ID NO: 14, SEQ ID NO: 22, or SEQ ID NO: 30, and CDRL3 of the amino acid sequence of SEQ ID NO: 7, SEQ ID NO: 15, SEQ ID NO: 23, or SEQ ID NO: 31.
Inventors:
KIM YONG IN (KR)
Application Number:
PCT/KR2022/003351
Publication Date:
October 27, 2022
Filing Date:
March 10, 2022
Export Citation:
Assignee:
NEORTESBIO INC (KR)
International Classes:
C07K16/22; A61K39/00; A61P25/28; A61P27/02; A61P35/00; C07K16/28
Domestic Patent References:
| WO2013028442A1 | 2013-02-28 |
Foreign References:
| KR20150136031A | 2015-12-04 | |||
| US20150079112A1 | 2015-03-19 | |||
| KR20190100060A | 2019-08-28 | |||
| EP2679599B1 | 2018-01-03 | |||
| KR20200144536A | 2020-12-29 | |||
| KR20150136031A | 2015-12-04 | |||
| US10934350B2 | 2021-03-02 |
Other References:
KABAT ET AL.: "Ann. NY Acad, Sci", vol. 190, 1971, pages: 382 - 391
KABAT, E. A. ET AL.: "Sequences of proteins of immunological interest", 1991, NATIONAL INSTITUTES OF HEALTH
SCHWABER, JCOHEN, E. P.: "Human x Mouse Somatic Cell Hybrid Clones Secreting Immunoglobulins of Both Parental Types", NATURE, vol. 244, 1973, pages 444 - 447
ALMAGRO, J. C.FRANSSON, J.: "Humanization of antibodies", FRONTIERS IN BIOSCIENCE, vol. 13, 2008, pages 1619 - 1633
KOHLERMILSTEIN, EUR. J IMMUNOL., vol. 6, 1976, pages 511
MEYER L ET AL.: "A simplified workflow for monoclonal antibody sequencing", PLOS ONE, 2019
KABAT, E. A. ET AL.: "Sequences of proteins of immunological interest", 1991, NATIONAL INSTITUTES OF HEALTH
SCHWABER, JCOHEN, E. P.: "Human x Mouse Somatic Cell Hybrid Clones Secreting Immunoglobulins of Both Parental Types", NATURE, vol. 244, 1973, pages 444 - 447
ALMAGRO, J. C.FRANSSON, J.: "Humanization of antibodies", FRONTIERS IN BIOSCIENCE, vol. 13, 2008, pages 1619 - 1633
KOHLERMILSTEIN, EUR. J IMMUNOL., vol. 6, 1976, pages 511
MEYER L ET AL.: "A simplified workflow for monoclonal antibody sequencing", PLOS ONE, 2019
Attorney, Agent or Firm:
KOO, Hyun Seo (KR)
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