Title:
ANTIBODY SYNTHETIC BACTERIUM-NANO STIMULATOR HYBRID AND ANTI-TUMOR APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/109704
Kind Code:
A1
Abstract:
Disclosed are an antibody synthetic bacterium-nano stimulator hybrid novel targeted drug delivery system, and an application thereof in the field of anti-tumor immunotherapy, and particularly disclosed are a pH response copolymer, a nano stimulator, an antibody synthetic bacterium, an antibody synthetic bacterium-nano stimulator hybrid system and a preparation method therefor and an application thereof.
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Inventors:
CAI LINTAO (CN)
LIAO JIANHONG (CN)
ZHENG MINGBIN (CN)
PAN HONG (CN)
ZHANG BAOZHEN (CN)
HUANG GUOJUN (CN)
TANG XIAOFAN (CN)
LIAO JIANHONG (CN)
ZHENG MINGBIN (CN)
PAN HONG (CN)
ZHANG BAOZHEN (CN)
HUANG GUOJUN (CN)
TANG XIAOFAN (CN)
Application Number:
PCT/CN2022/138176
Publication Date:
June 22, 2023
Filing Date:
December 09, 2022
Export Citation:
Assignee:
SHENZHEN INST ADV TECH (CN)
International Classes:
A61K35/74; C08G73/02; A61K38/20; A61P35/00; B82Y5/00; C07K16/28; C08G65/333; C12N15/74; G01N33/53
Foreign References:
| CN114349950A | 2022-04-15 | |||
| US20150273071A1 | 2015-10-01 | |||
| CN112673092A | 2021-04-16 | |||
| CN111358811A | 2020-07-03 | |||
| US20190017050A1 | 2019-01-17 |
Other References:
WANG, YI ET AL.: "Polymeric Nanoparticles Promote Macrophage Reversal from M2 to M1 Phenotypes in the Tumor Microenvironment", BIOMATERIALS, vol. 112, 4 October 2016 (2016-10-04), XP029812695, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2016.09.034
MORENO VÍCTOR M., ÁLVAREZ ELENA, IZQUIERDO‐BARBA ISABEL, BAEZA ALEJANDRO, SERRANO‐LÓPEZ JUANA, VALLET‐REGÍ MARÍA: "Bacteria as Nanoparticles Carrier for Enhancing Penetration in a Tumoral Matrix Model", ADVANCED MATERIALS INTERFACES, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 7, no. 11, 1 June 2020 (2020-06-01), DE , pages 1901942, XP093073699, ISSN: 2196-7350, DOI: 10.1002/admi.201901942
YIN, QI ET AL.: "Bioreducible Micelles with Endosomal Buffering and Multidrug Resistance-Reversing Function Enhance Anti-Tumor Efficacy of Doxorubicin", JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, vol. 11, no. 10, 1 October 2015 (2015-10-01), pages 1764 - 1775, XP009547223, ISSN: 1550-7033
ANDERSON, D. G. ET AL.: "Semi-Automated Synthesis and Screening of a Large Library of Degradable Cationic Polymers for Gene Delivery", ANGEWANDTE CHEMIE, vol. 42, no. 27, 10 July 2003 (2003-07-10), XP001196690, ISSN: 1521-3773, DOI: 10.1002/anie.200351244
PAN HONG, ZHENG MINGBIN, MA AIQING, LIU LANLAN, CAI LINTAO: "Cell/Bacteria‐Based Bioactive Materials for Cancer Immune Modulation and Precision Therapy", ADVANCED MATERIALS, VCH PUBLISHERS, DE, vol. 33, no. 50, 1 December 2021 (2021-12-01), DE , pages 2100241, XP093073704, ISSN: 0935-9648, DOI: 10.1002/adma.202100241
MORENO VÍCTOR M., ÁLVAREZ ELENA, IZQUIERDO‐BARBA ISABEL, BAEZA ALEJANDRO, SERRANO‐LÓPEZ JUANA, VALLET‐REGÍ MARÍA: "Bacteria as Nanoparticles Carrier for Enhancing Penetration in a Tumoral Matrix Model", ADVANCED MATERIALS INTERFACES, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 7, no. 11, 1 June 2020 (2020-06-01), DE , pages 1901942, XP093073699, ISSN: 2196-7350, DOI: 10.1002/admi.201901942
YIN, QI ET AL.: "Bioreducible Micelles with Endosomal Buffering and Multidrug Resistance-Reversing Function Enhance Anti-Tumor Efficacy of Doxorubicin", JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, vol. 11, no. 10, 1 October 2015 (2015-10-01), pages 1764 - 1775, XP009547223, ISSN: 1550-7033
ANDERSON, D. G. ET AL.: "Semi-Automated Synthesis and Screening of a Large Library of Degradable Cationic Polymers for Gene Delivery", ANGEWANDTE CHEMIE, vol. 42, no. 27, 10 July 2003 (2003-07-10), XP001196690, ISSN: 1521-3773, DOI: 10.1002/anie.200351244
PAN HONG, ZHENG MINGBIN, MA AIQING, LIU LANLAN, CAI LINTAO: "Cell/Bacteria‐Based Bioactive Materials for Cancer Immune Modulation and Precision Therapy", ADVANCED MATERIALS, VCH PUBLISHERS, DE, vol. 33, no. 50, 1 December 2021 (2021-12-01), DE , pages 2100241, XP093073704, ISSN: 0935-9648, DOI: 10.1002/adma.202100241
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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