Title:
ANTICANCER THERANOSTIC COMPOUNDS HAVING HEPATOCELLULAR CARCINOMA SPECIFICITY
Document Type and Number:
WIPO Patent Application WO/2021/118328
Kind Code:
A3
Abstract:
The present invention relates to an anticancer theranostic compound having hepatocellular carcinoma specificity, which is represented by the following chemical formula 1: (I) Provided according to the present invention can be a small molecule-based drug delivery system that is capable of both selective diagnosis and treatment of hepatocellular carcinoma (HCC). In addition, the anticancer theranostic compound according to the present invention is not only effectively accumulated in hepatocellular carcinoma, but also is activated in cancer cells, thereby exhibiting an excellent therapeutic effect.
Inventors:
KIM JONG SEUNG (KR)
SHARMA AMIT (KR)
JI MYUNG SUN (KR)
KIM EUN-JOONG (KR)
SHARMA AMIT (KR)
JI MYUNG SUN (KR)
KIM EUN-JOONG (KR)
Application Number:
PCT/KR2020/018291
Publication Date:
July 29, 2021
Filing Date:
December 14, 2020
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
A61K31/704; A61K47/18; A61K47/54; A61P35/00
Foreign References:
| US20140051623A1 | 2014-02-20 |
Other References:
SHARMA AMIT, LEE MIN-GOO, SHI HU, WON MIAE, ARAMBULA JONATHAN F., SESSLER JONATHAN L., LEE JIN YONG, CHI SUNG-GIL, KIM JONG SEUNG: "Overcoming Drug Resistance by Targeting Cancer Bioenergetics with an Activatable Prodrug", CHEM, vol. 4, no. 10, 11 October 2018 (2018-10-11), pages 2370 - 2383, XP055830832, ISSN: 2451-9294, DOI: 10.1016/j.chempr.2018.08.002
DAVID J. BURKHART, BENJAMIN L. BARTHEL, GLEN C. POST, BRIAN T. KALET, JORDAN W. NAFIE, RICHARD K. SHOEMAKER, TAD H. KOCH: "Design, Synthesis, and Preliminary Evaluation of Doxazolidine Carbamates as Prodrugs Activated by Carboxylesterases", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, no. 24, 30 November 2006 (2006-11-30), pages 7002 - 7012, XP055830834, ISSN: 0022-2623, DOI: 10.1021/jm060597e
HOCHDÖRFFER K, ABU AJAJ K, SCHÄFER-OBODOZIE C, KRATZ F.: "Development of novel bisphosphonate prodrugs of doxorubicin for targeting bone metastases that are cleaved pH dependently or by cathepsin B: synthesis, cleavage properties, and binding properties to hydroxyapatite as well as bone matrix.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 17, 13 September 2012 (2012-09-13), pages 7502 - 7515, XP002736394, ISSN: 0022-2623, DOI: 10.1021/jm300493m
MINGZHOU YE, YUXIN HAN, JIANBIN TANG, YING PIAO, XIANGRUI LIU, ZHUXIAN ZHOU, JIANQING GAO, JIANGHONG RAO, YOUQING SHEN: "A Tumor-Specific Cascade Amplification Drug Release Nanoparticle for Overcoming Multidrug Resistance in Cancers", ADVANCED MATERIALS, vol. 29, no. 38, 1702342, 1 October 2017 (2017-10-01), pages 1 - 10, XP055830836, ISSN: 0935-9648, DOI: 10.1002/adma.201702342
SHARMA AMIT, KIM EUN-JOONG, MUN SEOKGYU, JI MYUNG SUN, CHUNG BONG GEUN, KIM JONG SEUNG: "Molecular theranostic based on esterase-mediated drug activation for hepatocellular carcinoma", DYES AND PIGMENTS, vol. 163, 1 April 2019 (2019-04-01), pages 628 - 633, XP055830839, ISSN: 0143-7208, DOI: 10.1016/j.dyepig.2018.12.026
DAVID J. BURKHART, BENJAMIN L. BARTHEL, GLEN C. POST, BRIAN T. KALET, JORDAN W. NAFIE, RICHARD K. SHOEMAKER, TAD H. KOCH: "Design, Synthesis, and Preliminary Evaluation of Doxazolidine Carbamates as Prodrugs Activated by Carboxylesterases", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, no. 24, 30 November 2006 (2006-11-30), pages 7002 - 7012, XP055830834, ISSN: 0022-2623, DOI: 10.1021/jm060597e
HOCHDÖRFFER K, ABU AJAJ K, SCHÄFER-OBODOZIE C, KRATZ F.: "Development of novel bisphosphonate prodrugs of doxorubicin for targeting bone metastases that are cleaved pH dependently or by cathepsin B: synthesis, cleavage properties, and binding properties to hydroxyapatite as well as bone matrix.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 17, 13 September 2012 (2012-09-13), pages 7502 - 7515, XP002736394, ISSN: 0022-2623, DOI: 10.1021/jm300493m
MINGZHOU YE, YUXIN HAN, JIANBIN TANG, YING PIAO, XIANGRUI LIU, ZHUXIAN ZHOU, JIANQING GAO, JIANGHONG RAO, YOUQING SHEN: "A Tumor-Specific Cascade Amplification Drug Release Nanoparticle for Overcoming Multidrug Resistance in Cancers", ADVANCED MATERIALS, vol. 29, no. 38, 1702342, 1 October 2017 (2017-10-01), pages 1 - 10, XP055830836, ISSN: 0935-9648, DOI: 10.1002/adma.201702342
SHARMA AMIT, KIM EUN-JOONG, MUN SEOKGYU, JI MYUNG SUN, CHUNG BONG GEUN, KIM JONG SEUNG: "Molecular theranostic based on esterase-mediated drug activation for hepatocellular carcinoma", DYES AND PIGMENTS, vol. 163, 1 April 2019 (2019-04-01), pages 628 - 633, XP055830839, ISSN: 0143-7208, DOI: 10.1016/j.dyepig.2018.12.026
Attorney, Agent or Firm:
JUNG, Eun Youl et al. (KR)
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