Title:
ANTISENSE MODULATION OF VITAMIN D NUCLEAR RECEPTOR EXPRESSION
Document Type and Number:
WIPO Patent Application WO2003041657
Kind Code:
A3
Abstract:
Antisense compounds, compositions and methods are provided for modulating the expression of vitamin D nuclear receptor. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding vitamin D nuclear receptor. Methods are provided for using these compounds for modulation of vitamin D nuclear receptor expression, including examples of modulation of specific variants of vitamin D nuclear receptor relative to other variants. Methods for treatment of diseases associated with expression of vitamin D nuclear receptor are provided.
Inventors:
BAKER BRENDA F (US)
DOBIE KENNETH (US)
ROACH MARK P (US)
DOBIE KENNETH (US)
ROACH MARK P (US)
Application Number:
PCT/US2002/036692
Publication Date:
December 18, 2003
Filing Date:
November 13, 2002
Export Citation:
Assignee:
ISIS PHARMACEUTICALS INC (US)
BAKER BRENDA F (US)
DOBIE KENNETH (US)
ROACH MARK P (US)
BAKER BRENDA F (US)
DOBIE KENNETH (US)
ROACH MARK P (US)
International Classes:
C12N15/113; A61K38/00; (IPC1-7): C12Q1/68; A01N43/04; C07H21/04; A61K31/07
Foreign References:
| US5801154A | 1998-09-01 |
Other References:
HMAMA ET AL.: "1 alpha, 25-Dihydroxyvitamin D3-induced myeloid cell differentiation is regulated by a vitamin D receptor-phosphatidylinositol 3-kinase signaling complex", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 190, 6 December 1999 (1999-12-06), pages 1583 - 1594, XP002962226
FRITZ ET AL.: "Cationic polystyrene nanoparticles: preparation and characterization of a model drug carrier system for antisense oligonucleotides", JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 195, 1997, pages 272 - 288, XP002961842
WEINTRAUB M.: "Antisense RNA and DNA: molecules that bind with specific messenger RNA's can selectively turn of genes. Eventuallycertain diseases may be treated with them: today antisense molecules are valuable research tools", SCIENTIFIC AMERICAN, vol. 262, January 1990 (1990-01-01), pages 40 - 46, XP002951218
BRANCH A.: "A good antisense is hard to find", TIBS, vol. 23, February 1998 (1998-02-01), pages 45 - 50, XP002947100
JEN ET AL.: "Suppression of gene expression by targeted disruption of messenger RNA: available options and current strategies", STEM CELLS, vol. 18, 2000, pages 307 - 319, XP002948605
FRITZ ET AL.: "Cationic polystyrene nanoparticles: preparation and characterization of a model drug carrier system for antisense oligonucleotides", JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 195, 1997, pages 272 - 288, XP002961842
WEINTRAUB M.: "Antisense RNA and DNA: molecules that bind with specific messenger RNA's can selectively turn of genes. Eventuallycertain diseases may be treated with them: today antisense molecules are valuable research tools", SCIENTIFIC AMERICAN, vol. 262, January 1990 (1990-01-01), pages 40 - 46, XP002951218
BRANCH A.: "A good antisense is hard to find", TIBS, vol. 23, February 1998 (1998-02-01), pages 45 - 50, XP002947100
JEN ET AL.: "Suppression of gene expression by targeted disruption of messenger RNA: available options and current strategies", STEM CELLS, vol. 18, 2000, pages 307 - 319, XP002948605
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