Title:
ANTISENSE NUCLEIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1992/008729
Kind Code:
A1
Abstract:
A compound represented by general formula (1), its salt, and antiviral and antitumor drugs containing the same, wherein k is 0 to 20; m is 0 or 1; n is 4 to 29; X represents OH, methyl, sulfhydryl, C1 to C4 alkoxy or C1 to C6 monoalkylamino; Y and Z represent each O or S; R1, R2 and R3 may be the same or different from each other and each represents H, C1 to C6 alkyl, or C6 to C10 aryl which may have the substitutent(s) of group alpha; and D and B represent each independently a residue of any of the compounds of group beta; provided that m is 0 when k is 0, and a base sequence containing B is complementary to a tumor gene or a virus gene: group alpha: OH, C1 to C6 alkyl, C1 to C6 alkoxy, methylenedioxy, nitro, azido, halogen, C6 to C10 aryl, C6 to C10 aryloxy, and aralkyloxy composed of a C6 to C10 aryl moiety and a C1 to C2 alkyl moiety, group beta: adenine, guanine, cytosine and thymine.
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Inventors:
FURUKAWA HIDEHIKO (JP)
MOMOTA KENJI (JP)
TAKIGUCHI YO (JP)
HOTODA HITOSHI (JP)
KANEKO MASAKATSU (JP)
MOMOTA KENJI (JP)
TAKIGUCHI YO (JP)
HOTODA HITOSHI (JP)
KANEKO MASAKATSU (JP)
Application Number:
PCT/JP1991/001572
Publication Date:
May 29, 1992
Filing Date:
November 18, 1991
Export Citation:
Assignee:
SANKYO CO (JP)
International Classes:
A61K31/70; A61K47/48; A61P31/12; A61P35/00; C07H21/00; C07H21/04; C12N15/00; C12N15/09; C12N15/113; (IPC1-7): A61K31/70; C07H21/04
Foreign References:
| US4469863A | 1984-09-04 | |||
| EP0288163A2 | 1988-10-26 | |||
| EP0339842A2 | 1989-11-02 |
Other References:
Science, Vol. 248, p. 208-211 (13. 04. 1990), H. M. BUCK et al. "Phosphate-Mothylated DNA Aimet at HIV-1 RNA Loops and Integratea DNA Inhibitors Viral In fectivity".
See also references of EP 0558749A4
See also references of EP 0558749A4
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