Title:
ANTITUMOR AGENT, BACTERIA, AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2023/223870
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a technique useful for the treatment or diagnosis of cancer. The present invention provides an antitumor agent including bacteria isolated from a tumor. The bacteria may be, for example, bacteria belonging to the genus Proteus. The antitumor agent may be administered parenterally. In addition, the present invention also provides a method for producing bacteria having an anti-tumor activity, the method comprising: an isolation step for isolating bacteria from a tumor; and a culturing step for culturing, in a medium, the bacteria isolated in the isolation step.
More Like This:
Inventors:
MIYAKO EIJIRO (JP)
Application Number:
PCT/JP2023/017325
Publication Date:
November 23, 2023
Filing Date:
May 08, 2023
Export Citation:
Assignee:
JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECH (JP)
International Classes:
A61K35/74; A61K35/744; A61P35/00; C12N1/20; C12N15/09
Domestic Patent References:
| WO2016079733A1 | 2016-05-26 |
Other References:
MURATA, T. ; ARAKAWA, M. ; SUGIYA, Y. ; INAZU, Y. ; HATTORI, Z. ; SUZUKI, Y. ; MINAKAMI, H. ; NAKAHARA, M. ; OKAZAKI, H.: "Oncolytic effect of proteus mirabilis upon tumor bearing animal", LIFE SCIENCE, PERGAMON PRESS, OXFORD, GB, vol. 4, no. 10, 1 May 1965 (1965-05-01), GB , pages 1055 - 1067, XP025525744, ISSN: 0024-3205, DOI: 10.1016/0024-3205(65)90225-0
YANG XI, KOMATSU SATORU, REGHU SHEETHAL, MIYAKO EIJIRO: "Optically activatable photosynthetic bacteria-based highly tumor specific immunotheranostics", NANO TODAY, ELSEVIER, AMSTERDAM, NL, vol. 37, 1 April 2021 (2021-04-01), NL , pages 1 - 14, XP093027033, ISSN: 1748-0132, DOI: 10.1016/j.nantod.2021.101100
YONG A. YU; QIAN ZHANG; ALADAR A. SZALAY: "Establishment and characterization of conditions required for tumor colonization by intravenously delivered bacteria", BIOTECHNOLOGY AND BIOENGINEERING, JOHN WILEY, HOBOKEN, USA, vol. 100, no. 3, 8 January 2008 (2008-01-08), Hoboken, USA, pages 567 - 578, XP071153113, ISSN: 0006-3592, DOI: 10.1002/bit.21785
RIUS-ROCABERT SERGIO, LLINARES PINEL FRANCISCO, POZUELO MARIA JOSE, GARCÍA ANTONIA, NISTAL-VILLAN ESTANISLAO: "Oncolytic bacteria: past, present and future", FEMS MICROBIOLOGY LETTERS AUG 2009, vol. 366, no. 12, 1 June 2019 (2019-06-01), pages 1 - 26, XP093110709, ISSN: 1574-6968, DOI: 10.1093/femsle/fnz136
GOTO YAMATO, IWATA SEIGO, MIYAHARA MIKAKO, MIYAKO EIJIRO: "Discovery of Intratumoral Oncolytic Bacteria Toward Targeted Anticancer Theranostics", ADVANCED SCIENCE, vol. 10, no. 20, 1 July 2023 (2023-07-01), pages 2301679, XP093110721, ISSN: 2198-3844, DOI: 10.1002/advs.202301679
YANG XI, KOMATSU SATORU, REGHU SHEETHAL, MIYAKO EIJIRO: "Optically activatable photosynthetic bacteria-based highly tumor specific immunotheranostics", NANO TODAY, ELSEVIER, AMSTERDAM, NL, vol. 37, 1 April 2021 (2021-04-01), NL , pages 1 - 14, XP093027033, ISSN: 1748-0132, DOI: 10.1016/j.nantod.2021.101100
YONG A. YU; QIAN ZHANG; ALADAR A. SZALAY: "Establishment and characterization of conditions required for tumor colonization by intravenously delivered bacteria", BIOTECHNOLOGY AND BIOENGINEERING, JOHN WILEY, HOBOKEN, USA, vol. 100, no. 3, 8 January 2008 (2008-01-08), Hoboken, USA, pages 567 - 578, XP071153113, ISSN: 0006-3592, DOI: 10.1002/bit.21785
RIUS-ROCABERT SERGIO, LLINARES PINEL FRANCISCO, POZUELO MARIA JOSE, GARCÍA ANTONIA, NISTAL-VILLAN ESTANISLAO: "Oncolytic bacteria: past, present and future", FEMS MICROBIOLOGY LETTERS AUG 2009, vol. 366, no. 12, 1 June 2019 (2019-06-01), pages 1 - 26, XP093110709, ISSN: 1574-6968, DOI: 10.1093/femsle/fnz136
GOTO YAMATO, IWATA SEIGO, MIYAHARA MIKAKO, MIYAKO EIJIRO: "Discovery of Intratumoral Oncolytic Bacteria Toward Targeted Anticancer Theranostics", ADVANCED SCIENCE, vol. 10, no. 20, 1 July 2023 (2023-07-01), pages 2301679, XP093110721, ISSN: 2198-3844, DOI: 10.1002/advs.202301679
Attorney, Agent or Firm:
WATANABE Kaoru (JP)
Download PDF: