Title:
ANTIVIRAL AGENT, PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING VIRAL INFECTION, KIT FOR EVALUATING RISK OF VIRAL INFECTION BECOMING SEVERE, AND METHOD FOR EVALUATING RISK OF VIRAL INFECTION BECOMING SEVERE
Document Type and Number:
WIPO Patent Application WO/2024/010036
Kind Code:
A1
Abstract:
The present invention provides an antiviral agent containing, as an active ingredient, a protein having a disulfide bond cleavage action. The present invention also provides a pharmaceutical composition for treating or preventing viral infections, the pharmaceutical composition comprising the antiviral agent and a pharmaceutically acceptable carrier. The present invention further provides a kit for evaluating the risk of a viral infection becoming severe, the kit comprising a substance that specifically binds to a protein having a disulfide bond cleavage action. Further provided is a method for evaluating the risk of a viral infection becoming severe, the method comprising a step of measuring, in a biological sample from a subject, the blood concentration of a protein having a disulfide bond cleavage action.
Inventors:
OKUMURA MASAKI (JP)
TAKAYAMA KAZUO (JP)
HASHIMOTO RINA (JP)
KANEMURA SHINGO (JP)
TAKAYAMA KAZUO (JP)
HASHIMOTO RINA (JP)
KANEMURA SHINGO (JP)
Application Number:
PCT/JP2023/024953
Publication Date:
January 11, 2024
Filing Date:
July 05, 2023
Export Citation:
Assignee:
UNIV TOHOKU (JP)
UNIV KYOTO (JP)
KWANSEI GAKUIN EDUCATIONAL FOUND (JP)
UNIV KYOTO (JP)
KWANSEI GAKUIN EDUCATIONAL FOUND (JP)
International Classes:
C12N15/61; A61K38/52; A61K48/00; A61P31/12; C07K16/40; C12N9/90; C12Q1/533
Domestic Patent References:
| WO2021138682A1 | 2021-07-08 |
Other References:
WANG BIN, ZHANG JING, LIU XIN, CHAI QINGQING, LU XIAORAN, YAO XIAOYU, YANG ZHICHANG, SUN LIANGLIANG, JOHNSON SILAS F., SCHWARTZ RI: "Protein disulfide isomerases (PDIs) negatively regulate ebolavirus structural glycoprotein expression in the endoplasmic reticulum (ER) via the autophagy-lysosomal pathway", AUTOPHAGY, LANDES BIOSCIENCE, US, vol. 18, no. 10, 3 October 2022 (2022-10-03), US , pages 2350 - 2367, XP093125739, ISSN: 1554-8627, DOI: 10.1080/15548627.2022.2031381
SUGITA YUKIHIKO: "1. Ebola virus", VIRUS, vol. 69, no. 2, 1 December 2019 (2019-12-01), pages 119 - 128, XP093125755
SUHAIL SHANZAY; ZAJAC JONATHAN; FOSSUM CARL; LOWATER HARRISON; MCCRACKEN CAILIN; SEVERSON NATHANIEL; LAATSCH BETHANY; NARKIEWICZ-J: "Role of Oxidative Stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) Infection: A Review", PROTEIN JOURNAL, KLUWER ACADEMIC/PLENUM PUBLISHERS, DORDRECHT, NL, vol. 39, no. 6, 1 January 1900 (1900-01-01), NL , pages 644 - 656, XP037313655, ISSN: 1572-3887, DOI: 10.1007/s10930-020-09935-8
GEREZ GUILLAUME, MARTINEZ JEROME, STEINBRUGGER CHRISTOPHE, BOUANICH SANDRA, DIMINO JOHANNA, PIEGAY CORINE, COMBE MAXIME, BERTHIER : "Impact of SARS-CoV-2 RBD Mutations on the Production of a Recombinant RBD Fusion Protein in Mammalian Cells", BIOMOLECULES, M D P I AG, CH, vol. 12, no. 9, 24 August 2022 (2022-08-24), CH , pages 1170, XP093125746, ISSN: 2218-273X, DOI: 10.3390/biom12091170
SUGITA YUKIHIKO: "1. Ebola virus", VIRUS, vol. 69, no. 2, 1 December 2019 (2019-12-01), pages 119 - 128, XP093125755
SUHAIL SHANZAY; ZAJAC JONATHAN; FOSSUM CARL; LOWATER HARRISON; MCCRACKEN CAILIN; SEVERSON NATHANIEL; LAATSCH BETHANY; NARKIEWICZ-J: "Role of Oxidative Stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) Infection: A Review", PROTEIN JOURNAL, KLUWER ACADEMIC/PLENUM PUBLISHERS, DORDRECHT, NL, vol. 39, no. 6, 1 January 1900 (1900-01-01), NL , pages 644 - 656, XP037313655, ISSN: 1572-3887, DOI: 10.1007/s10930-020-09935-8
GEREZ GUILLAUME, MARTINEZ JEROME, STEINBRUGGER CHRISTOPHE, BOUANICH SANDRA, DIMINO JOHANNA, PIEGAY CORINE, COMBE MAXIME, BERTHIER : "Impact of SARS-CoV-2 RBD Mutations on the Production of a Recombinant RBD Fusion Protein in Mammalian Cells", BIOMOLECULES, M D P I AG, CH, vol. 12, no. 9, 24 August 2022 (2022-08-24), CH , pages 1170, XP093125746, ISSN: 2218-273X, DOI: 10.3390/biom12091170
Attorney, Agent or Firm:
TAZAKI Akira et al. (JP)
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