Title:
ANTIVIRAL ANTISENSE OLIGOMER
Document Type and Number:
WIPO Patent Application WO/2023/171804
Kind Code:
A1
Abstract:
The present specification provides an antisense oligomer that has a length of 15-30 bases and that has a base sequence complementary to the base sequence of a target region, a pharmaceutically acceptable salt thereof, or a hydrate of the same. The target region has: a base sequence that is consecutive by at least 10 times and that is in at least one region selected from the group consisting of the 5' UTR region, the nsp1 region, the nsp10 region, the RNA-dependent RNA polymerase region, the ORF10 region, and the 3' UTR region in the genome RNA of SARS-CoV-2; or a sequence complementary to said base sequence. The antisense oligomer, or the pharmaceutically acceptable salt thereof, or the hydrate of the same has an antiviral effect with respect to a virus selected from the group consisting of SARS-CoV-2, SARS-CoV-1, and MERS-CoV.
More Like This:
Inventors:
NAKAGAWA SHINICHIRO (JP)
TAGAYA MITSUHIRO (JP)
HIMOTO TAKUYA (JP)
KAMITANI WATARU (JP)
TAGAYA MITSUHIRO (JP)
HIMOTO TAKUYA (JP)
KAMITANI WATARU (JP)
Application Number:
PCT/JP2023/009404
Publication Date:
September 14, 2023
Filing Date:
March 10, 2023
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
UNIV GUNMA NAT UNIV CORP (JP)
UNIV GUNMA NAT UNIV CORP (JP)
International Classes:
C12N15/113; A61K31/7088; A61K31/7125; A61K31/787; A61K48/00; A61P31/12; C07H21/04
Domestic Patent References:
| WO2021226485A2 | 2021-11-11 | |||
| WO2022031410A1 | 2022-02-10 | |||
| WO2023074748A1 | 2023-05-04 | |||
| WO2022230974A1 | 2022-11-03 |
Foreign References:
| US20210317457A1 | 2021-10-14 |
Other References:
ROSENKE KYLE, LEVENTHAL SHANNA, MOULTON HONG M, HATLEVIG SUSAN, HAWMAN DAVID, FELDMANN HEINZ, STEIN DAVID A: "Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino oligomers", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, OXFORD UNIVERSITY PRESS, GB, vol. 76, no. 2, 19 January 2021 (2021-01-19), GB , pages 413 - 417, XP093091631, ISSN: 0305-7453, DOI: 10.1093/jac/dkaa460
HEGDE SHALAKHA, TANG ZHICHAO, ZHAO JUNXING, WANG JINGXIN: "Inhibition of SARS-CoV-2 by Targeting Conserved Viral RNA Structures and Sequences", FRONTIERS IN CHEMISTRY, vol. 9, XP093091632, DOI: 10.3389/fchem.2021.802766
LULLA VALERIA, WANDEL MICHAL P, BANDYRA KATARZYNA J, ULFERTS RACHEL, WU MARY, DENDOOVEN TOM, YANG XIAOFEI, DOYLE NICOLE, OERUM STE: "Targeting the Conserved Stem Loop 2 Motif in the SARS-CoV-2 Genome VACCINES AND ANTIVIRAL AGENTS", JOURNAL OF VIROLOGY, 24 June 2021 (2021-06-24), XP055886910, DOI: 10.1128/JVI.00663-21
WU FAN; ZHAO SU; YU BIN; CHEN YAN-MEI; WANG WEN; SONG ZHI-GANG; HU YI; TAO ZHAO-WU; TIAN JUN-HUA; PEI YUAN-YUAN; YUAN MING-LI; ZHA: "A new coronavirus associated with human respiratory disease in China", NATURE, vol. 579, no. 7798, 3 February 2020 (2020-02-03), pages 265 - 269, XP037060203, DOI: 10.1038/s41586-020-2008-3
DATABASE NUCLEOTIDE GENBANK; 18 July 2020 (2020-07-18), ANONYMOUS : "Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome", XP055780561, Database accession no. NC_045512
HEGDE SHALAKHA, TANG ZHICHAO, ZHAO JUNXING, WANG JINGXIN: "Inhibition of SARS-CoV-2 by Targeting Conserved Viral RNA Structures and Sequences", FRONTIERS IN CHEMISTRY, vol. 9, XP093091632, DOI: 10.3389/fchem.2021.802766
LULLA VALERIA, WANDEL MICHAL P, BANDYRA KATARZYNA J, ULFERTS RACHEL, WU MARY, DENDOOVEN TOM, YANG XIAOFEI, DOYLE NICOLE, OERUM STE: "Targeting the Conserved Stem Loop 2 Motif in the SARS-CoV-2 Genome VACCINES AND ANTIVIRAL AGENTS", JOURNAL OF VIROLOGY, 24 June 2021 (2021-06-24), XP055886910, DOI: 10.1128/JVI.00663-21
WU FAN; ZHAO SU; YU BIN; CHEN YAN-MEI; WANG WEN; SONG ZHI-GANG; HU YI; TAO ZHAO-WU; TIAN JUN-HUA; PEI YUAN-YUAN; YUAN MING-LI; ZHA: "A new coronavirus associated with human respiratory disease in China", NATURE, vol. 579, no. 7798, 3 February 2020 (2020-02-03), pages 265 - 269, XP037060203, DOI: 10.1038/s41586-020-2008-3
DATABASE NUCLEOTIDE GENBANK; 18 July 2020 (2020-07-18), ANONYMOUS : "Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome", XP055780561, Database accession no. NC_045512
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
Download PDF:
Previous Patent: ADHESIVE FILM AND METHOD FOR PRODUCING ADHESIVE FILM
Next Patent: DECORATIVE SHEET AND METHOD FOR PRODUCING DECORATIVE SHEET
Next Patent: DECORATIVE SHEET AND METHOD FOR PRODUCING DECORATIVE SHEET