Title:
ANTIVIRAL COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/040496
Kind Code:
A1
Abstract:
Disclosed are an antiviral compound, and a preparation method therefor and a use thereof, particularly an anti-coronavirus compound capable of being used as a PLpro inhibitor, and a preparation method therefor and a use thereof. The compound has a structure shown in general formula I, has high inhibitory activity, even dozens of times higher than that of known PLpro inhibitors, can be used for broad-spectrum antiviral purposes, especially for coronavirus such as SARS-CoV, MERS-CoV and SARS-CoV-2, and has very good potential application prospects in the pharmaceutical field.
Inventors:
HE WEI (CN)
LIU LEI (CN)
LI BIN (CN)
XU LIQIAN (CN)
LI HAOXIANG (CN)
ZHENG JIQING (CN)
WAN SHIZHANG (CN)
WU CAI (CN)
WANG TIAN (CN)
WANG MEIJING (CN)
LIU LEI (CN)
LI BIN (CN)
XU LIQIAN (CN)
LI HAOXIANG (CN)
ZHENG JIQING (CN)
WAN SHIZHANG (CN)
WU CAI (CN)
WANG TIAN (CN)
WANG MEIJING (CN)
Application Number:
PCT/CN2022/114689
Publication Date:
February 29, 2024
Filing Date:
August 25, 2022
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
International Classes:
C07D295/155; A61K31/496; A61P31/14; C07D295/215
Domestic Patent References:
| WO2010022355A1 | 2010-02-25 | |||
| WO2022070048A1 | 2022-04-07 |
Foreign References:
| CN114957165A | 2022-08-30 |
Attorney, Agent or Firm:
BEIJING IPLING INTELLECTUAL PROPERTY LAW FIRM (CN)
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