Title:
ANTIVIRAL COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/040497
Kind Code:
A1
Abstract:
An antiviral compound, a preparation method therefor and an use thereof; specifically an anti-coronavirus compound that can be used as a PLPro inhibitor, a preparation method therefor and a use thereof. The compound has a structure represented by general formula I. It has high inhibitory activity, can be used as a broad-spectrum antiviral, especially for coronaviruses (such as SARS-CoV, MERS-CoV and SARS-CoV-2), and has very good potential application prospects in the pharmaceutical field.
Inventors:
HE WEI (CN)
LIU LEI (CN)
LI BIN (CN)
XU LIQIAN (CN)
LI HAOXIANG (CN)
ZHENG JIQING (CN)
WAN SHIZHANG (CN)
WU CAI (CN)
WANG TIAN (CN)
WANG MEIJING (CN)
LIU LEI (CN)
LI BIN (CN)
XU LIQIAN (CN)
LI HAOXIANG (CN)
ZHENG JIQING (CN)
WAN SHIZHANG (CN)
WU CAI (CN)
WANG TIAN (CN)
WANG MEIJING (CN)
Application Number:
PCT/CN2022/114690
Publication Date:
February 29, 2024
Filing Date:
August 25, 2022
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
International Classes:
C07C237/38; A61K31/166; A61K31/18; A61K31/44; A61K31/505; A61P31/14; C07D213/81; C07D239/28
Domestic Patent References:
| WO2010022355A1 | 2010-02-25 | |||
| WO2021189046A1 | 2021-09-23 | |||
| WO2022070048A1 | 2022-04-07 |
Foreign References:
| CN114957165A | 2022-08-30 | |||
| CN114957110A | 2022-08-30 |
Other References:
FREITAS BRENDAN T., AHIADORME DANIIL A., BAGUL RAHUL S., DURIE IAN A., GHOSH SAMIR, HILL JARVIS, KRAMER NAOMI E., MURRAY JACKELYN,: "Exploring Noncovalent Protease Inhibitors for the Treatment of Severe Acute Respiratory Syndrome and Severe Acute Respiratory Syndrome-Like Coronaviruses", ACS INFECTIOUS DISEASES, AMERICAN CHEMICAL SOCIETY, US, vol. 8, no. 3, 11 March 2022 (2022-03-11), US , pages 596 - 611, XP093144399, ISSN: 2373-8227, DOI: 10.1021/acsinfecdis.1c00631
Attorney, Agent or Firm:
BEIJING IPLING INTELLECTUAL PROPERTY LAW FIRM (CN)
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