Title:
APPLICATION OF BZP IN TREATMENT OF ISCHEMIC CARDIOVASCULAR AND CEREBRAL VASCULAR DISEASES
Document Type and Number:
WIPO Patent Application WO/2022/089544
Kind Code:
A1
Abstract:
The present invention relates to an application of 5-bromo-2-(α-hydroxyamyl) sodium benzoate salt (BZP) in treatment of ischemic cardiovascular and cerebral vascular diseases, in particular to a BZP compound for treatment of ischemic stroke and a treatment method, and more specifically, relates to a treatment solution for treating mild and moderate acute ischemic stroke by using the BZP and a pharmaceutical composition comprising the BZP.
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Inventors:
ZHENG ZHIGUO (CN)
Application Number:
PCT/CN2021/127101
Publication Date:
May 05, 2022
Filing Date:
October 28, 2021
Export Citation:
Assignee:
ZHEJIANG AUSUN PHARMACEUTICAL CO LTD (CN)
International Classes:
A61P9/10; A61K31/192
Domestic Patent References:
| WO2015007181A1 | 2015-01-22 |
Foreign References:
| CN101402565A | 2009-04-08 | |||
| US20160168069A1 | 2016-06-16 |
Other References:
GAO YUAN, LI MIAO, WANG YAN, LI ZHENGQI, FAN CHENYU, WANG ZHENG, CAO XINYU, CHANG JUNBIAO, QIAO HAILING: "Protective Effects of Sodium (±)-5-Bromo-2-(α-Hydroxypentyl) Benzoate in a Rodent Model of Global Cerebral Ischemia", FRONTIERS IN PHARMACOLOGY, vol. 8, 27 September 2017 (2017-09-27), pages 1 - 10, XP055926556, DOI: 10.3389/fphar.2017.00691
GAO YUAN, WANG YAN, LI MIAO, LIU YALI, CHANG JUNBIAO, QIAO HAILING: "Preventive and therapeutic effect of brozopine on stroke in Dahl Salt-sensitive hypertensive rats", BRAIN RESEARCH, vol. 1672, 1 October 2017 (2017-10-01), NL , pages 137 - 147, XP055926558, ISSN: 0006-8993, DOI: 10.1016/j.brainres.2017.07.019
TIAN XIN, LIU BINGJIE, ZHANG YUHAI, LI HONGMENG, WEI JINGYAO, WANG GAOJU, CHANG JUNBIAO, QIAO HAILING: "LC-MS/MS Analysis and Pharmacokinetics of Sodium (±)-5-Bromo-2-(α-hydroxypentyl) Benzoate (BZP), an Innovative Potent Anti-Ischemic Stroke Agent in Rats", MOLECULES, vol. 21, no. 4, 16 April 2016 (2016-04-16), pages 1 - 12, XP055926560, DOI: 10.3390/molecules21040501
GAO YUAN, WANG YAN, LI MIAO, LIU YALI, CHANG JUNBIAO, QIAO HAILING: "Preventive and therapeutic effect of brozopine on stroke in Dahl Salt-sensitive hypertensive rats", BRAIN RESEARCH, vol. 1672, 1 October 2017 (2017-10-01), NL , pages 137 - 147, XP055926558, ISSN: 0006-8993, DOI: 10.1016/j.brainres.2017.07.019
TIAN XIN, LIU BINGJIE, ZHANG YUHAI, LI HONGMENG, WEI JINGYAO, WANG GAOJU, CHANG JUNBIAO, QIAO HAILING: "LC-MS/MS Analysis and Pharmacokinetics of Sodium (±)-5-Bromo-2-(α-hydroxypentyl) Benzoate (BZP), an Innovative Potent Anti-Ischemic Stroke Agent in Rats", MOLECULES, vol. 21, no. 4, 16 April 2016 (2016-04-16), pages 1 - 12, XP055926560, DOI: 10.3390/molecules21040501
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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