Title:
APPLICATION OF EXOSOMES MICRORNA AND MRNA AND KIT OF EXOSOMES MICRORNA AND MRNA
Document Type and Number:
WIPO Patent Application WO/2023/134037
Kind Code:
A1
Abstract:
The present invention relates to the technical field of biology, and in particular to an application of exosomes microRNA and mRNA and a kit of the exosomes microRNA and mRNA. The present invention proves by means of experiments that the urine exosomes miR-1307-3p and KIF5C have remarkable differences in expression in normal people and patients with Parkinson's disease, indicating that the urine exosomes miR-1307-3p and KIF5C can become molecular markers for screening and/or diagnosing Parkinson's disease. The two molecular markers can be combined to accurately distinguish the patients with Parkinson's disease from healthy people, and early screening and diagnosis of Parkinson's disease are achieved.
Inventors:
WANG WEIPENG (CN)
QIU TIAN (CN)
XIONG KANGPING (CN)
YANG MAN (CN)
WANG MENGMENG (CN)
QIU TIAN (CN)
XIONG KANGPING (CN)
YANG MAN (CN)
WANG MENGMENG (CN)
Application Number:
PCT/CN2022/086214
Publication Date:
July 20, 2023
Filing Date:
April 12, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C12N15/11; C12Q1/6883; C12Q1/6851
Domestic Patent References:
| WO2016196822A1 | 2016-12-08 |
Foreign References:
| CN114214404A | 2022-03-22 | |||
| US20140302068A1 | 2014-10-09 | |||
| US20150366897A1 | 2015-12-24 | |||
| CN113755597A | 2021-12-07 |
Other References:
EVANS BRIAN, FURLONG HOWARD A., DE LENCASTRE ALEXANDRE: "Parkinson's disease and microRNAs - Lessons from model organisms and human studies", EXPERIMENTAL GERONTOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 155, 1 November 2021 (2021-11-01), AMSTERDAM, NL , pages 111585, XP093078220, ISSN: 0531-5565, DOI: 10.1016/j.exger.2021.111585
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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